Detailed information of TA system TA234094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4495598..4496200
• Replicon: chromosome
• Accession: NZ_CP091624
• Organism: Salmonella enterica strain 1382

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5508_RS21505
• Protein ID: WP_001159630.1
• Coordinates: 4495889..4496200 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5508_RS21500
• Protein ID: WP_000362050.1
• Coordinates: 4495598..4495888 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5508_RS21485 (4493091)	4493091..4493993	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5508_RS21490 (4493990)	4493990..4494625	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5508_RS21495 (4494622)	4494622..4495551	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5508_RS21500 (4495598)	4495598..4495888	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5508_RS21505 (4495889)	4495889..4496200	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5508_RS21510 (4496418)	4496418..4497347	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5508_RS21515 (4497433)	4497433..4497744	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
L5508_RS21520 (4497741)	4497741..4498187	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
L5508_RS21525 (4498202)	4498202..4499143	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5508_RS21530 (4499188)	4499188..4499625	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5508_RS21535 (4499622)	4499622..4500494	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5508_RS21540 (4500488)	4500488..4501087	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T234094 WP_001159630.1 NZ_CP091624:c4496200-4495889 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T234094 NZ_LR025101:3060441-3060815 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT234094 WP_000362050.1 NZ_CP091624:c4495888-4495598 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT234094 NZ_LR025101:3059984-3060352 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64