Detailed information of TA system TA234075

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4464664..4465266
• Replicon: chromosome
• Accession: NZ_CP091622
• Organism: Salmonella enterica strain 1419

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5509_RS21330
• Protein ID: WP_001159630.1
• Coordinates: 4464955..4465266 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5509_RS21325
• Protein ID: WP_000362050.1
• Coordinates: 4464664..4464954 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5509_RS21310 (4462157)	4462157..4463059	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5509_RS21315 (4463056)	4463056..4463691	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5509_RS21320 (4463688)	4463688..4464617	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5509_RS21325 (4464664)	4464664..4464954	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5509_RS21330 (4464955)	4464955..4465266	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5509_RS21335 (4465484)	4465484..4466413	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5509_RS21340 (4466499)	4466499..4466810	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
L5509_RS21345 (4466807)	4466807..4467253	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
L5509_RS21350 (4467268)	4467268..4468209	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5509_RS21355 (4468254)	4468254..4468691	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5509_RS21360 (4468688)	4468688..4469560	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5509_RS21365 (4469554)	4469554..4470153	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T234075 WP_001159630.1 NZ_CP091622:c4465266-4464955 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T234075 NZ_LR025099:c5000447-5000079 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT234075 WP_000362050.1 NZ_CP091622:c4464954-4464664 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT234075 NZ_LR025099:c5000665-5000444 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64