Detailed information of TA system TA234056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4454504..4455258
• Replicon: chromosome
• Accession: NZ_CP091619
• Organism: Salmonella enterica strain 1473

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: L5510_RS21265
• Protein ID: WP_133323219.1
• Coordinates: 4454504..4454815 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5510_RS21270
• Protein ID: WP_001259009.1
• Coordinates: 4454812..4455258 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5510_RS21235 (4450162)	4450162..4451064	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5510_RS21240 (4451061)	4451061..4451696	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5510_RS21245 (4451693)	4451693..4452622	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5510_RS21250 (4452669)	4452669..4452959	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
L5510_RS21255 (4452960)	4452960..4453271	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
L5510_RS21260 (4453489)	4453489..4454418	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5510_RS21265 (4454504)	4454504..4454815	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	Toxin
L5510_RS21270 (4454812)	4454812..4455258	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
L5510_RS21275 (4455273)	4455273..4456214	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5510_RS21280 (4456259)	4456259..4456696	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5510_RS21285 (4456693)	4456693..4457565	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5510_RS21290 (4457559)	4457559..4458158	-	600	WP_000965698.1	glucose-1-phosphatase	-
L5510_RS21295 (4458349)	4458349..4459152	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
L5510_RS21300 (4459186)	4459186..4460082	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12490.44 Da
• Isoelectric Point: 9.1995

>T234056 WP_133323219.1 NZ_CP091619:4454504-4454815 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T234056 NZ_LR025096:2329103-2329279 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT234056 WP_001259009.1 NZ_CP091619:4454812-4455258 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT234056 NZ_LR025096:2329325-2329741 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA