Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4452669..4453271 Replicon chromosome
Accession NZ_CP091619
Organism Salmonella enterica strain 1473

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag L5510_RS21255 Protein ID WP_001159630.1
Coordinates 4452960..4453271 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L5510_RS21250 Protein ID WP_000362050.1
Coordinates 4452669..4452959 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5510_RS21235 (4450162) 4450162..4451064 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
L5510_RS21240 (4451061) 4451061..4451696 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
L5510_RS21245 (4451693) 4451693..4452622 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
L5510_RS21250 (4452669) 4452669..4452959 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
L5510_RS21255 (4452960) 4452960..4453271 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
L5510_RS21260 (4453489) 4453489..4454418 + 930 WP_001127694.1 alpha/beta hydrolase -
L5510_RS21265 (4454504) 4454504..4454815 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin -
L5510_RS21270 (4454812) 4454812..4455258 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
L5510_RS21275 (4455273) 4455273..4456214 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
L5510_RS21280 (4456259) 4456259..4456696 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
L5510_RS21285 (4456693) 4456693..4457565 - 873 WP_000921423.1 virulence factor BrkB family protein -
L5510_RS21290 (4457559) 4457559..4458158 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T234055 WP_001159630.1 NZ_CP091619:c4453271-4452960 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T234055 NZ_LR025096:c2127229-2127122 [Escherichia coli]
ATGACGCTCGCGCAGTTTACCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT234055 WP_000362050.1 NZ_CP091619:c4452959-4452669 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT234055 NZ_LR025096:2127276-2127342 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References