Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2320237..2320739 Replicon chromosome
Accession NC_011748
Organism Escherichia coli 55989

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EC55989_RS11760 Protein ID WP_000767829.1
Coordinates 2320237..2320491 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EC55989_RS11765 Protein ID WP_001259255.1
Coordinates 2320488..2320739 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC55989_RS11735 2315252..2315479 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
EC55989_RS11740 2315493..2316551 - 1059 WP_000492324.1 transport protein YeeE -
EC55989_RS11745 2316730..2318088 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EC55989_RS28805 2318078..2318140 - 63 WP_010723108.1 membrane protein YoeI -
EC55989_RS11750 2318355..2319284 - 930 WP_000803366.1 LysR family transcriptional regulator -
EC55989_RS11755 2319330..2320154 - 825 WP_000754758.1 SDR family oxidoreductase -
EC55989_RS11760 2320237..2320491 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EC55989_RS11765 2320488..2320739 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EC55989_RS26675 2321023..2321073 + 51 WP_001364200.1 his operon leader peptide -
EC55989_RS11770 2321219..2322118 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
EC55989_RS11775 2322124..2323428 + 1305 WP_001386882.1 histidinol dehydrogenase -
EC55989_RS11780 2323425..2324495 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
EC55989_RS11785 2324495..2325562 + 1068 WP_000080087.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T23402 WP_000767829.1 NC_011748:c2320491-2320237 [Escherichia coli 55989]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T23402 NC_011748:c2320491-2320237 [Escherichia coli 55989]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT23402 WP_001259255.1 NC_011748:c2320739-2320488 [Escherichia coli 55989]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT23402 NC_011748:c2320739-2320488 [Escherichia coli 55989]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References