Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4489574..4490328 Replicon chromosome
Accession NZ_CP091611
Organism Salmonella enterica strain 1795

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L5512_RS21505 Protein ID WP_133323219.1
Coordinates 4489574..4489885 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L5512_RS21510 Protein ID WP_001259009.1
Coordinates 4489882..4490328 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5512_RS21475 (4485232) 4485232..4486134 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
L5512_RS21480 (4486131) 4486131..4486766 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
L5512_RS21485 (4486763) 4486763..4487692 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
L5512_RS21490 (4487739) 4487739..4488029 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
L5512_RS21495 (4488030) 4488030..4488341 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
L5512_RS21500 (4488559) 4488559..4489488 + 930 WP_001127694.1 alpha/beta hydrolase -
L5512_RS21505 (4489574) 4489574..4489885 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
L5512_RS21510 (4489882) 4489882..4490328 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
L5512_RS21515 (4490343) 4490343..4491284 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
L5512_RS21520 (4491329) 4491329..4491766 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
L5512_RS21525 (4491763) 4491763..4492635 - 873 WP_000921423.1 virulence factor BrkB family protein -
L5512_RS21530 (4492629) 4492629..4493228 - 600 WP_000965698.1 glucose-1-phosphatase -
L5512_RS21535 (4493419) 4493419..4494222 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
L5512_RS21540 (4494256) 4494256..4495152 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T234014 WP_133323219.1 NZ_CP091611:4489574-4489885 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T234014 NZ_LN999829:c1224376-1223630 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
AGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTAGTAGGCGCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGGAGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGGACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT234014 WP_001259009.1 NZ_CP091611:4489882-4490328 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT234014 NZ_LN999829:c1223629-1223459 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAATCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References