Detailed information of TA system TA234013

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4487739..4488341
• Replicon: chromosome
• Accession: NZ_CP091611
• Organism: Salmonella enterica strain 1795

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5512_RS21495
• Protein ID: WP_001159630.1
• Coordinates: 4488030..4488341 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5512_RS21490
• Protein ID: WP_000362050.1
• Coordinates: 4487739..4488029 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5512_RS21475 (4485232)	4485232..4486134	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5512_RS21480 (4486131)	4486131..4486766	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5512_RS21485 (4486763)	4486763..4487692	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5512_RS21490 (4487739)	4487739..4488029	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5512_RS21495 (4488030)	4488030..4488341	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5512_RS21500 (4488559)	4488559..4489488	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5512_RS21505 (4489574)	4489574..4489885	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
L5512_RS21510 (4489882)	4489882..4490328	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
L5512_RS21515 (4490343)	4490343..4491284	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5512_RS21520 (4491329)	4491329..4491766	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5512_RS21525 (4491763)	4491763..4492635	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5512_RS21530 (4492629)	4492629..4493228	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T234013 WP_001159630.1 NZ_CP091611:c4488341-4488030 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T234013 NZ_LN999829:464488-464838 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT234013 WP_000362050.1 NZ_CP091611:c4488029-4487739 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT234013 NZ_LN999829:464201-464482 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64