Detailed information of TA system TA233995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4497475..4498229
• Replicon: chromosome
• Accession: NZ_CP091607
• Organism: Salmonella enterica strain 1810

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: L5513_RS21525
• Protein ID: WP_133323219.1
• Coordinates: 4497475..4497786 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5513_RS21530
• Protein ID: WP_001259009.1
• Coordinates: 4497783..4498229 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5513_RS21495 (4493133)	4493133..4494035	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5513_RS21500 (4494032)	4494032..4494667	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5513_RS21505 (4494664)	4494664..4495593	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5513_RS21510 (4495640)	4495640..4495930	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
L5513_RS21515 (4495931)	4495931..4496242	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
L5513_RS21520 (4496460)	4496460..4497389	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5513_RS21525 (4497475)	4497475..4497786	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	Toxin
L5513_RS21530 (4497783)	4497783..4498229	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
L5513_RS21535 (4498244)	4498244..4499185	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5513_RS21540 (4499230)	4499230..4499667	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5513_RS21545 (4499664)	4499664..4500536	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5513_RS21550 (4500530)	4500530..4501129	-	600	WP_000965698.1	glucose-1-phosphatase	-
L5513_RS21555 (4501320)	4501320..4502123	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
L5513_RS21560 (4502157)	4502157..4503053	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12490.44 Da
• Isoelectric Point: 9.1995

>T233995 WP_133323219.1 NZ_CP091607:4497475-4497786 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T233995 NZ_LN907829:97609-97875 [Erwinia gerundensis]
TTGGTCTGGACGATTAACTATTCCGACCGGGCGCTCAAATCGTTACGTAAGATGGACAAGCAAAACGCGCGACGGATTGT
GGATTTTATGGATTTACGCATTGCTGCTGCCGCCGATCCGCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGTTATCGGGTCGGTGATTATCGTATCCTGTGTGAAATCAGGGACGACGAGCTGGTTATTCTAGCGGCCACCATT
GGCCATCGACGTGAAGTCTACGACTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT233995 WP_001259009.1 NZ_CP091607:4497783-4498229 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT233995 NZ_LN907829:97401-97625 [Erwinia gerundensis]
ATGCTGGCTATCCGATTATCTGATGAGATTGAGGCACGTCTGGACTCGCTGGCAAAACAAACCGGCAGAACAAAGACGTT
CTATGCGCGGGAAGCGATACTGGCGCATCTGGAAGACTTGGAAGATTATTACCTTTCAGCAGAAACTGTGGCACGCGTTC
GCCGTGGCGATGAAAATGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA