Detailed information of TA system TA233994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4495640..4496242
• Replicon: chromosome
• Accession: NZ_CP091607
• Organism: Salmonella enterica strain 1810

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5513_RS21515
• Protein ID: WP_001159630.1
• Coordinates: 4495931..4496242 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5513_RS21510
• Protein ID: WP_000362050.1
• Coordinates: 4495640..4495930 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5513_RS21495 (4493133)	4493133..4494035	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5513_RS21500 (4494032)	4494032..4494667	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5513_RS21505 (4494664)	4494664..4495593	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5513_RS21510 (4495640)	4495640..4495930	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5513_RS21515 (4495931)	4495931..4496242	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5513_RS21520 (4496460)	4496460..4497389	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5513_RS21525 (4497475)	4497475..4497786	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
L5513_RS21530 (4497783)	4497783..4498229	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
L5513_RS21535 (4498244)	4498244..4499185	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5513_RS21540 (4499230)	4499230..4499667	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5513_RS21545 (4499664)	4499664..4500536	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5513_RS21550 (4500530)	4500530..4501129	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233994 WP_001159630.1 NZ_CP091607:c4496242-4495931 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233994 NZ_LN907828:244883-245299 [Erwinia gerundensis]
GTGAACAAAACCTTTATGCTGGACACCAACATCTGCTCGTTCATCATGCGCGAACAGCCGGAAGCCGTAATCAGAAGGCT
AGTGCAGACGGTGTTGCATAACCACCGCATTGTTGTCTCGGCCATCACTTATGCAGAAATGCGCTTTGGGACGATTAACA
AAAAAGCCTCGCCACGTCATGCGCAGATGGTTGACGCATTCTGTGCCCGACTCGATTCTATCCTACCCTGGGATCAGACA
GCAGTAGACGCAACCATGGAAATAAAGGCTGCGTTAGCCACCCTCGGGACGCCAATCGGGCCTAATGACACCGCCATTGC
AGGGCATGCCATCGCAGTTCAGGCTATTCTGGTGACTAATAATATCCGAGAATTTGAGGGGGTGTGCGGACTGATGCTGG
AAGACTGGGTTAATTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233994 WP_000362050.1 NZ_CP091607:c4495930-4495640 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233994 NZ_LN907828:244656-244886 [Erwinia gerundensis]
ATGAGAACCGTATCGATTTTTAAAAATGGTAATAACCGCGCCATACGTCTGCCCCGCGATCTGGACTTTGAAGGGGTTAG
CGAGCTGGAGATTATCCGCGAAGGTGACCGTATCATCCTGCGTCCCGTCCGGCCAACCTGGGGCTCTTTTAAAGAGCTTG
CAAAGGCCGACGCGGATTTTATGGCGGATCGCGAGGACGTTATCAGTGATGAAGGGCGATTTGACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64