Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4492202..4492956 Replicon chromosome
Accession NZ_CP091604
Organism Salmonella enterica strain 1902

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L5514_RS21510 Protein ID WP_133323219.1
Coordinates 4492202..4492513 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L5514_RS21515 Protein ID WP_001259009.1
Coordinates 4492510..4492956 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5514_RS21480 (4487860) 4487860..4488762 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
L5514_RS21485 (4488759) 4488759..4489394 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
L5514_RS21490 (4489391) 4489391..4490320 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
L5514_RS21495 (4490367) 4490367..4490657 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
L5514_RS21500 (4490658) 4490658..4490969 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
L5514_RS21505 (4491187) 4491187..4492116 + 930 WP_001127694.1 alpha/beta hydrolase -
L5514_RS21510 (4492202) 4492202..4492513 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
L5514_RS21515 (4492510) 4492510..4492956 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
L5514_RS21520 (4492971) 4492971..4493912 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
L5514_RS21525 (4493957) 4493957..4494394 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
L5514_RS21530 (4494391) 4494391..4495263 - 873 WP_000921423.1 virulence factor BrkB family protein -
L5514_RS21535 (4495257) 4495257..4495856 - 600 WP_000965698.1 glucose-1-phosphatase -
L5514_RS21540 (4496047) 4496047..4496850 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
L5514_RS21545 (4496884) 4496884..4497780 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T233976 WP_133323219.1 NZ_CP091604:4492202-4492513 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T233976 NZ_LN890521:64078-64560 [Salmonella enterica subsp. enterica serovar Weltevreden]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT233976 WP_001259009.1 NZ_CP091604:4492510-4492956 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT233976 NZ_LN890521:63803-64087 [Salmonella enterica subsp. enterica serovar Weltevreden]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References