Detailed information of TA system TA233975

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4490367..4490969
• Replicon: chromosome
• Accession: NZ_CP091604
• Organism: Salmonella enterica strain 1902

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5514_RS21500
• Protein ID: WP_001159630.1
• Coordinates: 4490658..4490969 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5514_RS21495
• Protein ID: WP_000362050.1
• Coordinates: 4490367..4490657 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5514_RS21480 (4487860)	4487860..4488762	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5514_RS21485 (4488759)	4488759..4489394	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5514_RS21490 (4489391)	4489391..4490320	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5514_RS21495 (4490367)	4490367..4490657	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5514_RS21500 (4490658)	4490658..4490969	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5514_RS21505 (4491187)	4491187..4492116	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5514_RS21510 (4492202)	4492202..4492513	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
L5514_RS21515 (4492510)	4492510..4492956	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
L5514_RS21520 (4492971)	4492971..4493912	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5514_RS21525 (4493957)	4493957..4494394	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5514_RS21530 (4494391)	4494391..4495263	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5514_RS21535 (4495257)	4495257..4495856	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233975 WP_001159630.1 NZ_CP091604:c4490969-4490658 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233975 NZ_LN890519:95843-96148 [Salmonella enterica subsp. enterica serovar Weltevreden]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233975 WP_000362050.1 NZ_CP091604:c4490657-4490367 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233975 NZ_LN890519:95623-95841 [Salmonella enterica subsp. enterica serovar Weltevreden]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64