Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1403683..1404269 Replicon chromosome
Accession NZ_CP091594
Organism Klebsiella pneumoniae strain Nord5-1_R48

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag L5467_RS09725 Protein ID WP_002920800.1
Coordinates 1403901..1404269 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag L5467_RS09720 Protein ID WP_004174006.1
Coordinates 1403683..1403904 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5467_RS09700 (1399840) 1399840..1400766 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
L5467_RS09705 (1400763) 1400763..1402040 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
L5467_RS09710 (1402037) 1402037..1402804 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
L5467_RS09715 (1402806) 1402806..1403519 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
L5467_RS09720 (1403683) 1403683..1403904 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L5467_RS09725 (1403901) 1403901..1404269 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
L5467_RS09730 (1404542) 1404542..1405858 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
L5467_RS09735 (1405965) 1405965..1406852 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
L5467_RS09740 (1406849) 1406849..1407694 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
L5467_RS09745 (1407696) 1407696..1408766 + 1071 WP_032433652.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1400763..1409503 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T233920 WP_002920800.1 NZ_CP091594:1403901-1404269 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T233920 NZ_LN865164:c2216425-2215850 [Pseudomonas sp. URMO17WK12:I11]
ATGAGGCACTCACCTTTTACAGTTATCTACGACGCCTGCGTGCTTTATCCAGCACCATTGCGTGACCTATTGATGCATCT
GGCTCTGACTGGCGCGTATCGCGCGCGCTGGTCCGAGCAAATCCACGATGAATGGACACGAAACGTGTTAAGAAACCGTC
CCGACGTGTCAGAAACACAACTTTATCGCACAGTCGGACTCATGAATCGGGCGATTCCTGACTCTCTGGTAAATGACTAC
GAGCCACTTGTGCAGGGGCTTGACCTTCCAGACGAAGACGATAGACACGTCTTGGCAGCAGCGATCAAATGTGGCGCCTC
GGTGATTGTCACGTACAACCTCAAAGATTTTCCGGCCGAGATTCTGAAACGTTTTGAGATCGAGGCGTTGCATCCCGATG
TATTCCTCTCCGACATCTGGGACCTTGACCAGGCAGCTGTGCTCAAGGCCGTCCAGAAGCAGCGCGCAGCCCTTAACAAT
CCGGTTTACTCACCCCGCGAGCTGCTGGACATCCTCCTCAAGCAGCGGCTCCCAGAGACCGTCAAGCACCTCTCGAACTA
CGAGCTGCTGATCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT233920 WP_004174006.1 NZ_CP091594:1403683-1403904 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT233920 NZ_LN865164:c2216889-2216422 [Pseudomonas sp. URMO17WK12:I11]
ATGACTACCGCCGATCTCGCTCAAGCCATCCTTCCAGATGAAAAAGCGATCACCGCGGCTATTGAGTCAAGCCGCCAGAT
TGCCGCGTTCGTCTCAACCAAGTTGGATACTCAGCGCATTGAGTTGGTAGATGAAGCCCAGCAACGGCAGACTGTTGAAC
TGCCAACGTTCGCGCTCAGATTGCTTGGCGACATACTCAACGAGCTGGCCTTGGGCAACACCGTAAAGGTGGTGCCTATC
CATGCGGAACTGACCACCCAGGAGGGCGCCGATATGCTCAACGTCTCGCGTCCTCACTTGGTCAAGCTGCTGGATGAGGG
GCTAATCCCACACACCAAAACCGGCAGCCACCGCCGTGTAAAATTTACTGACCTAATGGCCTACAAGGCCGATCGTGATA
AAGCAAGCCAGGCCGCCATGGATGAACTGGCTGCACAAGCCCAAGAACTTAATATGGGCTATCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References