Detailed information of TA system TA233887

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 77525..77778
• Replicon: 2 plasmid p2-4
• Accession: NZ_CP091574
• Organism: Salmonella enterica strain

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: G9G1E3
• Locus tag: INN74_RS26120
• Protein ID: WP_001312851.1
• Coordinates: 77629..77778 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	77525..77584 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN74_RS26095 (74252)	74252..74998	+	747	WP_000205770.1	conjugal transfer pilus acetylase TraX	-
INN74_RS26100 (75053)	75053..75613	+	561	WP_000139328.1	fertility inhibition protein FinO	-
INN74_RS26105 (75745)	75745..75945	+	201	WP_015059022.1	hypothetical protein	-
INN74_RS26110 (76331)	76331..76930	+	600	WP_032083981.1	PIN domain-containing protein	-
INN74_RS26115 (77094)	77094..77324	+	231	WP_001736714.1	hypothetical protein	-
- (77525)	77525..77584	-	60	NuclAT_1	-	Antitoxin
- (77525)	77525..77584	-	60	NuclAT_1	-	Antitoxin
- (77525)	77525..77584	-	60	NuclAT_1	-	Antitoxin
- (77525)	77525..77584	-	60	NuclAT_1	-	Antitoxin
INN74_RS26120 (77629)	77629..77778	+	150	WP_001312851.1	Hok/Gef family protein	Toxin
INN74_RS26125 (78062)	78062..78310	+	249	WP_000083837.1	replication regulatory protein RepA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	fosA3 / blaTEM-1B / blaCTX-M-55	-	1..78621	78621

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5542.67 Da
• Isoelectric Point: 8.7678

>T233887 WP_001312851.1 NZ_CP091574:77629-77778 [Salmonella enterica]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T233887 NZ_LN847264:326357-326647 [Pseudomonas sp. CCOS 191]
ATGCACACGCTCATACAGACCGACAGATACAAGAAGTGGTTTGCTGCCTTGCGGGATGCTCGCGCTCAGGCCCGCATCAA
CGTGCGGCTGCGGCGGGTCGAGCTTGGCGTGCTGGGGGATTGCAAGCCAGTGGGCGAGGGTGTTCTGGAGCTGAGAGTCG
ACTACGGGCCTGGCTATCGAGTCTATCTGGCCCGGCGCGGCTATGAGGTGATACTTCTCCTTGCCGGGGGAGACAAAACC
ACTCAAGCCCGCGACATCAAATCTGCACTCAAGCTGGCGCGTGATATCTAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT233887 NZ_CP091574:c77584-77525 [Salmonella enterica]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A829C8K5

Antitoxin