Detailed information of TA system TA233884

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 38029..38298
• Replicon: 2 plasmid p2-4
• Accession: NZ_CP091574
• Organism: Salmonella enterica strain

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: INN74_RS25890
• Protein ID: WP_001372321.1
• Coordinates: 38173..38298 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	38029..38094 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN74_RS25860	33739..34266	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
INN74_RS25865	34324..34557	+	234	WP_000006003.1	DUF905 family protein	-
INN74_RS25870	34618..36641	+	2024	Protein_44	ParB/RepB/Spo0J family partition protein	-
INN74_RS25875	36710..37144	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
INN74_RS25880	37141..37860	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	37872..38096	+	225	NuclAT_0	-	-
-	37872..38096	+	225	NuclAT_0	-	-
-	37872..38096	+	225	NuclAT_0	-	-
-	37872..38096	+	225	NuclAT_0	-	-
-	38029..38094	-	66	-	-	Antitoxin
INN74_RS25885	38082..38231	+	150	Protein_47	plasmid maintenance protein Mok	-
INN74_RS25890	38173..38298	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
INN74_RS25895	38617..38913	-	297	Protein_49	hypothetical protein	-
INN74_RS25900	39213..39509	+	297	WP_001272251.1	hypothetical protein	-
INN74_RS25905	39620..40441	+	822	WP_001234445.1	DUF932 domain-containing protein	-
INN74_RS25910	40738..41385	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
INN74_RS25915	41662..42045	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
INN74_RS25920	42236..42922	+	687	WP_015059009.1	PAS domain-containing protein	-
INN74_RS25925	43016..43243	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	fosA3 / blaTEM-1B / blaCTX-M-55	-	1..78621	78621

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T233884 WP_001372321.1 NZ_CP091574:38173-38298 [Salmonella enterica]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T233884 NZ_LN832559:2259678-2259932 [Paracoccus aminovorans]
ATGAAAAAGCGTCACAGAGCCACGCTGGAACTGATCTTCGCCCGCCCGGTCAATGGTTCGATCCGCTGGACCGACATAGA
GGCGCTGTTTGTGAGCCTCGGGGCGGAAGTCAGTGAGCGGGAAGGTTCGCGCGTCGGCGTGTTCCTGTTCGGCGAAGTGC
GCGTCTTTCATCGCCCGCATCCCTCACCGGATACGGACAAAGGTGCGGTTGCCAGCATCCGTAAATGGCTGGACGAACAC
GGAGTAAAGCCATGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT233884 NZ_CP091574:c38094-38029 [Salmonella enterica]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin