Detailed information of TA system TA233877

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4770164..4770766
• Replicon: chromosome
• Accession: NZ_CP091571
• Organism: Salmonella enterica strain

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: INN74_RS23240
• Protein ID: WP_001159630.1
• Coordinates: 4770455..4770766 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: INN74_RS23235
• Protein ID: WP_000362050.1
• Coordinates: 4770164..4770454 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN74_RS23220 (4767657)	4767657..4768559	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
INN74_RS23225 (4768556)	4768556..4769191	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
INN74_RS23230 (4769188)	4769188..4770117	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
INN74_RS23235 (4770164)	4770164..4770454	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
INN74_RS23240 (4770455)	4770455..4770766	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
INN74_RS23245 (4770984)	4770984..4771913	+	930	WP_249001115.1	alpha/beta hydrolase	-
INN74_RS23250 (4771999)	4771999..4772310	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
INN74_RS23255 (4772307)	4772307..4772753	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
INN74_RS23260 (4772768)	4772768..4773709	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
INN74_RS23265 (4773754)	4773754..4774191	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
INN74_RS23270 (4774188)	4774188..4775060	-	873	WP_000921427.1	virulence factor BrkB family protein	-
INN74_RS23275 (4775054)	4775054..4775653	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233877 WP_001159630.1 NZ_CP091571:c4770766-4770455 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233877 NZ_LN832404:c3230967-3230653 [Escherichia coli K-12]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233877 WP_000362050.1 NZ_CP091571:c4770454-4770164 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233877 NZ_LN832404:c3230656-3230240 [Escherichia coli K-12]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64