Detailed information of TA system TA233853

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4784135..4784889
• Replicon: chromosome
• Accession: NZ_CP091569
• Organism: Salmonella enterica strain 131

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: INN75_RS23445
• Protein ID: WP_000558166.1
• Coordinates: 4784135..4784446 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: INN75_RS23450
• Protein ID: WP_001259011.1
• Coordinates: 4784443..4784889 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN75_RS23415 (4779793)	4779793..4780695	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
INN75_RS23420 (4780692)	4780692..4781327	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
INN75_RS23425 (4781324)	4781324..4782253	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
INN75_RS23430 (4782300)	4782300..4782590	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
INN75_RS23435 (4782591)	4782591..4782902	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
INN75_RS23440 (4783120)	4783120..4784049	+	930	WP_001127703.1	alpha/beta hydrolase	-
INN75_RS23445 (4784135)	4784135..4784446	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
INN75_RS23450 (4784443)	4784443..4784889	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
INN75_RS23455 (4784904)	4784904..4785845	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
INN75_RS23460 (4785890)	4785890..4786327	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
INN75_RS23465 (4786324)	4786324..4787196	-	873	WP_000921427.1	virulence factor BrkB family protein	-
INN75_RS23470 (4787190)	4787190..4787789	-	600	WP_000965695.1	glucose-1-phosphatase	-
INN75_RS23475 (4787980)	4787980..4788783	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
INN75_RS23480 (4788817)	4788817..4789713	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T233853 WP_000558166.1 NZ_CP091569:4784135-4784446 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T233853 NZ_LN831051:1456991-1457245 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGCCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT233853 WP_001259011.1 NZ_CP091569:4784443-4784889 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT233853 NZ_LN831051:1456747-1456989 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAAATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Toxin

• AlphaFold DB: A0A0R9ME90