Detailed information of TA system TA233852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4782300..4782902
• Replicon: chromosome
• Accession: NZ_CP091569
• Organism: Salmonella enterica strain 131

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: INN75_RS23435
• Protein ID: WP_001159630.1
• Coordinates: 4782591..4782902 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: INN75_RS23430
• Protein ID: WP_000362050.1
• Coordinates: 4782300..4782590 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN75_RS23415 (4779793)	4779793..4780695	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
INN75_RS23420 (4780692)	4780692..4781327	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
INN75_RS23425 (4781324)	4781324..4782253	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
INN75_RS23430 (4782300)	4782300..4782590	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
INN75_RS23435 (4782591)	4782591..4782902	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
INN75_RS23440 (4783120)	4783120..4784049	+	930	WP_001127703.1	alpha/beta hydrolase	-
INN75_RS23445 (4784135)	4784135..4784446	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
INN75_RS23450 (4784443)	4784443..4784889	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
INN75_RS23455 (4784904)	4784904..4785845	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
INN75_RS23460 (4785890)	4785890..4786327	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
INN75_RS23465 (4786324)	4786324..4787196	-	873	WP_000921427.1	virulence factor BrkB family protein	-
INN75_RS23470 (4787190)	4787190..4787789	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233852 WP_001159630.1 NZ_CP091569:c4782902-4782591 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233852 NZ_LN831051:953076-953249 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCATATTAA
AATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233852 WP_000362050.1 NZ_CP091569:c4782590-4782300 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233852 NZ_LN831051:953286-953738 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64