Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | stbDE/ParE-YafN |
Location | 2448863..2449385 | Replicon | chromosome |
Accession | NZ_CP091569 | ||
Organism | Salmonella enterica strain 131 |
Toxin (Protein)
Gene name | stbE | Uniprot ID | B5F5Y5 |
Locus tag | INN75_RS12040 | Protein ID | WP_000221343.1 |
Coordinates | 2449101..2449385 (+) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | stbD | Uniprot ID | V1H457 |
Locus tag | INN75_RS12035 | Protein ID | WP_000885424.1 |
Coordinates | 2448863..2449111 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
INN75_RS12010 (2444079) | 2444079..2445545 | + | 1467 | WP_000987828.1 | hypothetical protein | - |
INN75_RS12015 (2446353) | 2446353..2447067 | + | 715 | Protein_2356 | helix-turn-helix domain-containing protein | - |
INN75_RS12020 (2447123) | 2447123..2448031 | - | 909 | WP_010989018.1 | hypothetical protein | - |
INN75_RS12025 (2448174) | 2448174..2448506 | - | 333 | WP_000253154.1 | DUF1493 family protein | - |
INN75_RS12030 (2448496) | 2448496..2448711 | - | 216 | WP_000206207.1 | hypothetical protein | - |
INN75_RS12035 (2448863) | 2448863..2449111 | + | 249 | WP_000885424.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
INN75_RS12040 (2449101) | 2449101..2449385 | + | 285 | WP_000221343.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
INN75_RS12045 (2449556) | 2449556..2449945 | + | 390 | WP_000194089.1 | RidA family protein | - |
INN75_RS12050 (2449997) | 2449997..2451076 | - | 1080 | WP_000954688.1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase | - |
INN75_RS12055 (2451355) | 2451355..2452329 | + | 975 | WP_012478345.1 | IS30-like element ISApl1 family transposase | - |
INN75_RS12060 (2452341) | 2452341..2452829 | - | 489 | WP_001293638.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
INN75_RS12065 (2452874) | 2452874..2454382 | + | 1509 | WP_000199411.1 | FAD-dependent oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 2444082..2457239 | 13157 | ||
- | flank | IS/Tn | - | - | 2451406..2452329 | 923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11075.85 Da Isoelectric Point: 10.6500
>T233844 WP_000221343.1 NZ_CP091569:2449101-2449385 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS
Download Length: 285 bp
>T233844 NZ_LN831036:c2485063-2484956 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9090.32 Da Isoelectric Point: 3.9820
>AT233844 WP_000885424.1 NZ_CP091569:2448863-2449111 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
Download Length: 249 bp
>AT233844 NZ_LN831036:2484879-2484939 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5H5JSW4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5I0WPN5 |