Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2448863..2449385 Replicon chromosome
Accession NZ_CP091569
Organism Salmonella enterica strain 131

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag INN75_RS12040 Protein ID WP_000221343.1
Coordinates 2449101..2449385 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag INN75_RS12035 Protein ID WP_000885424.1
Coordinates 2448863..2449111 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN75_RS12010 (2444079) 2444079..2445545 + 1467 WP_000987828.1 hypothetical protein -
INN75_RS12015 (2446353) 2446353..2447067 + 715 Protein_2356 helix-turn-helix domain-containing protein -
INN75_RS12020 (2447123) 2447123..2448031 - 909 WP_010989018.1 hypothetical protein -
INN75_RS12025 (2448174) 2448174..2448506 - 333 WP_000253154.1 DUF1493 family protein -
INN75_RS12030 (2448496) 2448496..2448711 - 216 WP_000206207.1 hypothetical protein -
INN75_RS12035 (2448863) 2448863..2449111 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INN75_RS12040 (2449101) 2449101..2449385 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN75_RS12045 (2449556) 2449556..2449945 + 390 WP_000194089.1 RidA family protein -
INN75_RS12050 (2449997) 2449997..2451076 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
INN75_RS12055 (2451355) 2451355..2452329 + 975 WP_012478345.1 IS30-like element ISApl1 family transposase -
INN75_RS12060 (2452341) 2452341..2452829 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
INN75_RS12065 (2452874) 2452874..2454382 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2444082..2457239 13157
- flank IS/Tn - - 2451406..2452329 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T233844 WP_000221343.1 NZ_CP091569:2449101-2449385 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T233844 NZ_LN831036:c2485063-2484956 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT233844 WP_000885424.1 NZ_CP091569:2448863-2449111 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT233844 NZ_LN831036:2484879-2484939 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References