Detailed information of TA system TA233811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 1437269..1437871
• Replicon: chromosome
• Accession: NZ_CP091566
• Organism: Salmonella enterica strain 137

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: INN76_RS07020
• Protein ID: WP_001159630.1
• Coordinates: 1437269..1437580 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: INN76_RS07025
• Protein ID: WP_000362050.1
• Coordinates: 1437581..1437871 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN76_RS06985 (1432382)	1432382..1432981	+	600	WP_000965695.1	glucose-1-phosphatase	-
INN76_RS06990 (1432975)	1432975..1433847	+	873	WP_000921427.1	virulence factor BrkB family protein	-
INN76_RS06995 (1433844)	1433844..1434281	+	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
INN76_RS07000 (1434326)	1434326..1435267	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
INN76_RS07005 (1435282)	1435282..1435728	-	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
INN76_RS07010 (1435725)	1435725..1436036	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
INN76_RS07015 (1436122)	1436122..1437051	-	930	WP_001127703.1	alpha/beta hydrolase	-
INN76_RS07020 (1437269)	1437269..1437580	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
INN76_RS07025 (1437581)	1437581..1437871	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
INN76_RS07030 (1437918)	1437918..1438847	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
INN76_RS07035 (1438844)	1438844..1439479	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
INN76_RS07040 (1439476)	1439476..1440378	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233811 WP_001159630.1 NZ_CP091566:1437269-1437580 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233811 NZ_LN831024:c143740-143459 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233811 WP_000362050.1 NZ_CP091566:1437581-1437871 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233811 NZ_LN831024:c143964-143737 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64