Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 875511..876049 Replicon chromosome
Accession NZ_CP091566
Organism Salmonella enterica strain 137

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag INN76_RS04395 Protein ID WP_001526148.1
Coordinates 875511..875786 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag INN76_RS04400 Protein ID WP_000729713.1
Coordinates 875789..876049 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN76_RS04390 (872718) 872718..875423 + 2706 WP_000907029.1 HTH-type transcriptional regulator MalT -
INN76_RS04395 (875511) 875511..875786 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
INN76_RS04400 (875789) 875789..876049 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
INN76_RS04405 (876158) 876158..877177 - 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
INN76_RS04410 (877181) 877181..878395 - 1215 WP_001105521.1 RNA-splicing ligase RtcB -
INN76_RS04415 (878743) 878743..878934 - 192 Protein_866 TROVE domain-containing protein -
INN76_RS04420 (878943) 878943..880496 - 1554 WP_000013007.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T233807 WP_001526148.1 NZ_CP091566:c875786-875511 [Salmonella enterica]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T233807 NZ_LN824140:c333643-333338 [Bifidobacterium longum subsp. infantis]
ATGGAAATCAAGCAAACCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGAACCGCGAGGCGAAAGCCGCCATCCAAGC
CCGGCTCGACGCCTGCAAGCTCGCCGGCAGGCCGTTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGT
TCCACATCGGAGCCGGATACCGCGTCTACTTCACCACGCGCGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAA
AGCACCCAGCAGACCGACATCAAACAAGCCCACGCCATACTCGACGACTACAAGGAGCAGCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT233807 WP_000729713.1 NZ_CP091566:c876049-875789 [Salmonella enterica]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT233807 NZ_LN824140:c333341-333057 [Bifidobacterium longum subsp. infantis]
ATGAGCACCGAAATCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATACGACGACCCCGCACTCATGCAGGCCGCACTCGGCAACGTCGCCAAGGCTCGAGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAAAGCCTCAGCAAGGACGGAAACCCCAGCTTCCAGACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References