Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4990185..4990787 Replicon chromosome
Accession NZ_CP091563
Organism Salmonella enterica strain 143

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag INN77_RS24605 Protein ID WP_001159630.1
Coordinates 4990185..4990496 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag INN77_RS24610 Protein ID WP_000362050.1
Coordinates 4990497..4990787 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN77_RS24570 (4985298) 4985298..4985897 + 600 WP_000965695.1 glucose-1-phosphatase -
INN77_RS24575 (4985891) 4985891..4986763 + 873 WP_000921427.1 virulence factor BrkB family protein -
INN77_RS24580 (4986760) 4986760..4987197 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
INN77_RS24585 (4987242) 4987242..4988183 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
INN77_RS24590 (4988198) 4988198..4988644 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
INN77_RS24595 (4988641) 4988641..4988952 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
INN77_RS24600 (4989038) 4989038..4989967 - 930 WP_001127703.1 alpha/beta hydrolase -
INN77_RS24605 (4990185) 4990185..4990496 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
INN77_RS24610 (4990497) 4990497..4990787 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
INN77_RS24615 (4990834) 4990834..4991763 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
INN77_RS24620 (4991760) 4991760..4992395 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
INN77_RS24625 (4992392) 4992392..4993294 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T233796 WP_001159630.1 NZ_CP091563:4990185-4990496 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T233796 NZ_LN824133:c3364864-3364762 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT233796 WP_000362050.1 NZ_CP091563:4990497-4990787 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT233796 NZ_LN824133:3364755-3364900 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References