Detailed information of TA system TA233795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4988198..4988952
• Replicon: chromosome
• Accession: NZ_CP091563
• Organism: Salmonella enterica strain 143

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: INN77_RS24595
• Protein ID: WP_000558166.1
• Coordinates: 4988641..4988952 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: INN77_RS24590
• Protein ID: WP_001259011.1
• Coordinates: 4988198..4988644 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN77_RS24560 (4983374)	4983374..4984270	+	897	WP_001520529.1	sugar kinase	-
INN77_RS24565 (4984304)	4984304..4985107	+	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
INN77_RS24570 (4985298)	4985298..4985897	+	600	WP_000965695.1	glucose-1-phosphatase	-
INN77_RS24575 (4985891)	4985891..4986763	+	873	WP_000921427.1	virulence factor BrkB family protein	-
INN77_RS24580 (4986760)	4986760..4987197	+	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
INN77_RS24585 (4987242)	4987242..4988183	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
INN77_RS24590 (4988198)	4988198..4988644	-	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
INN77_RS24595 (4988641)	4988641..4988952	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
INN77_RS24600 (4989038)	4989038..4989967	-	930	WP_001127703.1	alpha/beta hydrolase	-
INN77_RS24605 (4990185)	4990185..4990496	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
INN77_RS24610 (4990497)	4990497..4990787	+	291	WP_000362050.1	DNA-binding transcriptional regulator	-
INN77_RS24615 (4990834)	4990834..4991763	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
INN77_RS24620 (4991760)	4991760..4992395	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
INN77_RS24625 (4992392)	4992392..4993294	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T233795 WP_000558166.1 NZ_CP091563:c4988952-4988641 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T233795 NZ_LN824133:2630925-2632247 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT233795 WP_001259011.1 NZ_CP091563:c4988644-4988198 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT233795 NZ_LN824133:2630659-2630925 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Toxin

• AlphaFold DB: A0A0R9ME90