Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4792845..4793599 | Replicon | chromosome |
| Accession | NZ_CP091560 | ||
| Organism | Salmonella enterica strain 179 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | INN78_RS23540 | Protein ID | WP_000558166.1 |
| Coordinates | 4792845..4793156 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | INN78_RS23545 | Protein ID | WP_001259011.1 |
| Coordinates | 4793153..4793599 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| INN78_RS23510 (4788503) | 4788503..4789405 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| INN78_RS23515 (4789402) | 4789402..4790037 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| INN78_RS23520 (4790034) | 4790034..4790963 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| INN78_RS23525 (4791010) | 4791010..4791300 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| INN78_RS23530 (4791301) | 4791301..4791612 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| INN78_RS23535 (4791830) | 4791830..4792759 | + | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
| INN78_RS23540 (4792845) | 4792845..4793156 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| INN78_RS23545 (4793153) | 4793153..4793599 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| INN78_RS23550 (4793614) | 4793614..4794555 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| INN78_RS23555 (4794600) | 4794600..4795037 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| INN78_RS23560 (4795034) | 4795034..4795906 | - | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
| INN78_RS23565 (4795900) | 4795900..4796499 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| INN78_RS23570 (4796690) | 4796690..4797493 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| INN78_RS23575 (4797527) | 4797527..4798423 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T233771 WP_000558166.1 NZ_CP091560:4792845-4793156 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T233771 NZ_LN681227:2320543-2320821 [Xenorhabdus nematophila AN6/1]
ATGAACAAACAGGTTTCAGCGCTCCGAACGAGGCAACAACGTACCTTAGAACAAATTTTTAAAACGCCGGTATCGTCGGG
AATTAAATGGTCAGATATTGAATCGTTAATCAAGGCATTGGGCGGTGAAATCAAGGAAGGCCGAGGTTCGCGTTGTAAAT
TTTTACTGAATGGGAGTATTGCCAATTTTCATCGCCCCCATCCGTCACCCGACACAGACAAAGGGGCTGTGGCGGGATTA
CGGGAATGGTTGGAAAGTATAGGAGTCACACCATCATGA
ATGAACAAACAGGTTTCAGCGCTCCGAACGAGGCAACAACGTACCTTAGAACAAATTTTTAAAACGCCGGTATCGTCGGG
AATTAAATGGTCAGATATTGAATCGTTAATCAAGGCATTGGGCGGTGAAATCAAGGAAGGCCGAGGTTCGCGTTGTAAAT
TTTTACTGAATGGGAGTATTGCCAATTTTCATCGCCCCCATCCGTCACCCGACACAGACAAAGGGGCTGTGGCGGGATTA
CGGGAATGGTTGGAAAGTATAGGAGTCACACCATCATGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT233771 WP_001259011.1 NZ_CP091560:4793153-4793599 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT233771 NZ_LN681227:2320818-2321174 [Xenorhabdus nematophila AN6/1]
ATGAGTAAGCAAAATACCAATATTATGGAGATCGCCGGACTCTCGGCGGTGATTAGTTATGTCCCTGAACTCGGTATGTT
TCGGGGGAAGTTTTTAGGGTTATCCGGTTATTGTGATTTTGTGGCTGACAGTATTGCTGGGCTGCATGCTGAAGGGCGAT
TGTCTTTAGATGAATATTTAGAAGACTGCCGAGCCGCCAATATCGAGCCTTATCAGAAACGTGAAAAAACAAAAACGTTT
ACTTTACGTTACCCCGAATCGTTTGGCGAACGGTTAAATCAGGCTGCAACCGAACACCATATTTCGGTCAACGCGTTCAT
TTTGGAGACATTGGGTGAGCGCCTGAGAAACATCTAA
ATGAGTAAGCAAAATACCAATATTATGGAGATCGCCGGACTCTCGGCGGTGATTAGTTATGTCCCTGAACTCGGTATGTT
TCGGGGGAAGTTTTTAGGGTTATCCGGTTATTGTGATTTTGTGGCTGACAGTATTGCTGGGCTGCATGCTGAAGGGCGAT
TGTCTTTAGATGAATATTTAGAAGACTGCCGAGCCGCCAATATCGAGCCTTATCAGAAACGTGAAAAAACAAAAACGTTT
ACTTTACGTTACCCCGAATCGTTTGGCGAACGGTTAAATCAGGCTGCAACCGAACACCATATTTCGGTCAACGCGTTCAT
TTTGGAGACATTGGGTGAGCGCCTGAGAAACATCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|