Detailed information of TA system TA233770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4791010..4791612
• Replicon: chromosome
• Accession: NZ_CP091560
• Organism: Salmonella enterica strain 179

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: INN78_RS23530
• Protein ID: WP_001159630.1
• Coordinates: 4791301..4791612 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: INN78_RS23525
• Protein ID: WP_000362050.1
• Coordinates: 4791010..4791300 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN78_RS23510 (4788503)	4788503..4789405	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
INN78_RS23515 (4789402)	4789402..4790037	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
INN78_RS23520 (4790034)	4790034..4790963	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
INN78_RS23525 (4791010)	4791010..4791300	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
INN78_RS23530 (4791301)	4791301..4791612	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
INN78_RS23535 (4791830)	4791830..4792759	+	930	WP_001127703.1	alpha/beta hydrolase	-
INN78_RS23540 (4792845)	4792845..4793156	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
INN78_RS23545 (4793153)	4793153..4793599	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
INN78_RS23550 (4793614)	4793614..4794555	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
INN78_RS23555 (4794600)	4794600..4795037	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
INN78_RS23560 (4795034)	4795034..4795906	-	873	WP_000921427.1	virulence factor BrkB family protein	-
INN78_RS23565 (4795900)	4795900..4796499	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233770 WP_001159630.1 NZ_CP091560:c4791612-4791301 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233770 NZ_LN681227:2148414-2148902 [Xenorhabdus nematophila AN6/1]
GTGGGAATAAGTACGCCGGAAATCTTAACGGTTAAACATAATGTAAAGGATTTTTATTGCCAGCATGAAACATTAAACGA
ATGGCTTTCACGCCGGGCTTTAAAAAATAATAAGCTCGGCGCGAGCCGCACATTTGTTATTTGCAAGGAAGGAACAAAAG
ACGTTATCGGTTATTATTGTCTAAGTGCTGGTTCAATTAATCATATTGAATCTACACCATCCCTTAAACGCAATATGCCA
GATGCTATCCCTGTAATGTTGCTCGGCCGCCTAGCTGTTGATGCGGAATATCAGGGGAAGAAGCTCGGTGCATTACTTCT
TCAAGATGCTTGGAAGCGTGTTGCCAGTACGGCGGAACAGGTAGGCATTTCAGCGATAATTGTCCACGCATTTGATGAAA
GCGCCCGAACGTTCTATATGCGTCTTGGTTTCGTCCAGTCACCATTGGAGTCATATACACTGATGCTTCCATTAGGCAAA
CAGAACTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233770 WP_000362050.1 NZ_CP091560:c4791300-4791010 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233770 NZ_LN681227:2148151-2148423 [Xenorhabdus nematophila AN6/1]
ATGAGAACACAACCTAAAGAAACCCCGATTAACATCCGGGCGAAAGCCTTCCAGCGGGAGCTTATCGACCATGCAGCAAA
CCTACATTCGAAGACACGAACTGATTTCATCTTGGATGCTGCCTGCCGAGCTGCTGAAGAGGCCATACTCGATCAGCGCC
ACTTTTTTGTTAACGACGAAAAATATCAGGCGTTCATGCAGATGCTGGAACAACCGCTTTCTGATAACGCAGGTTTTAAA
AAGCTCATGGGATATAAAGCACCGTGGGAATAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64