233762

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2457307..2457829 Replicon chromosome
Accession NZ_CP091560
Organism Salmonella enterica strain 179

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag INN78_RS12135 Protein ID WP_000221343.1
Coordinates 2457545..2457829 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag INN78_RS12130 Protein ID WP_000885424.1
Coordinates 2457307..2457555 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN78_RS12105 (2452523) 2452523..2453989 + 1467 WP_000987828.1 hypothetical protein -
INN78_RS12110 (2454797) 2454797..2455511 + 715 Protein_2375 helix-turn-helix domain-containing protein -
INN78_RS12115 (2455567) 2455567..2456475 - 909 WP_010989018.1 hypothetical protein -
INN78_RS12120 (2456618) 2456618..2456950 - 333 WP_000253154.1 DUF1493 family protein -
INN78_RS12125 (2456940) 2456940..2457155 - 216 WP_000206207.1 hypothetical protein -
INN78_RS12130 (2457307) 2457307..2457555 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INN78_RS12135 (2457545) 2457545..2457829 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN78_RS12140 (2458000) 2458000..2458389 + 390 WP_000194089.1 RidA family protein -
INN78_RS12145 (2458441) 2458441..2459520 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
INN78_RS12150 (2459713) 2459713..2460201 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
INN78_RS12155 (2460246) 2460246..2461754 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2452526..2464611 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T233762 WP_000221343.1 NZ_CP091560:2457545-2457829 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T233762 NZ_LN681227:83020-83325 [Xenorhabdus nematophila AN6/1]
ATGCAGTACACAGTTTACAAAAATACAGGTAATCCTGATTATTCCTATCTGTTGGATGTTCAGAGCGACATTATTGATGT
ATTAGAAACACGATTGGTCATTCCATTATTCCTAAAATCAAATTTCCACGGGCGAATTCCAACTCGATTATGCCCGACCC
TGAACATTGATGGGAACGAATATCTCGTTATGACTCACGCGATGGCTAGCATCAGAGTCTCTATGTTAGGTGATGAGATG
ACAAATGTTTCATCCCACAGACAGCTAATTAAAGATGCGATGGATTTACTCTTTGACGGGTTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT233762 WP_000885424.1 NZ_CP091560:2457307-2457555 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT233762 NZ_LN681227:82779-83018 [Xenorhabdus nematophila AN6/1]
ATGACAGCATTACACTCCAGAACTAAAAAAACCGTCAGCGTGACTGTTTCACCAGAACTGTATGAACAAGCAAAACAAAT
AGGACTAAATTTTTCTGCTATTTTGACTCAGGCATTAATTGCAGAACTTAAATCTGCGGCGGCTGAGCAGTGGAAACGTG
ATAATAGGGAGGGATTCGAAGAACTCAATCGCATCACCCGTGAACATGGTCTACTGTCCGATCAATATAGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References