Detailed information of TA system TA233746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4975322..4975924
• Replicon: chromosome
• Accession: NZ_CP091558
• Organism: Salmonella enterica strain 418

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: INN79_RS24545
• Protein ID: WP_001159630.1
• Coordinates: 4975322..4975633 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: INN79_RS24550
• Protein ID: WP_000362050.1
• Coordinates: 4975634..4975924 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN79_RS24510 (4970435)	4970435..4971034	+	600	WP_000965695.1	glucose-1-phosphatase	-
INN79_RS24515 (4971028)	4971028..4971900	+	873	WP_000921427.1	virulence factor BrkB family protein	-
INN79_RS24520 (4971897)	4971897..4972334	+	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
INN79_RS24525 (4972379)	4972379..4973320	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
INN79_RS24530 (4973335)	4973335..4973781	-	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
INN79_RS24535 (4973778)	4973778..4974089	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
INN79_RS24540 (4974175)	4974175..4975104	-	930	WP_001127703.1	alpha/beta hydrolase	-
INN79_RS24545 (4975322)	4975322..4975633	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
INN79_RS24550 (4975634)	4975634..4975924	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
INN79_RS24555 (4975971)	4975971..4976900	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
INN79_RS24560 (4976897)	4976897..4977532	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
INN79_RS24565 (4977529)	4977529..4978431	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233746 WP_001159630.1 NZ_CP091558:4975322-4975633 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233746 NZ_LN649259:c2237775-2237524 [Bacillus subtilis]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATCAAAGATTACTTCAGCAGCGAAGGACAGGCGCTAA
TCAACACAATTTTTGTTGTCACATGTATCATTGCCATATTGTTATGGATCATCTATTGTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233746 WP_000362050.1 NZ_CP091558:4975634-4975924 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233746 NZ_LN649259:2237753-2237853 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Structures

Toxin

• AlphaFold DB: A0A0R9NS64