Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4973335..4974089 | Replicon | chromosome |
Accession | NZ_CP091558 | ||
Organism | Salmonella enterica strain 418 |
Toxin (Protein)
Gene name | higB | Uniprot ID | B5F003 |
Locus tag | INN79_RS24535 | Protein ID | WP_000558166.1 |
Coordinates | 4973778..4974089 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | INN79_RS24530 | Protein ID | WP_001259011.1 |
Coordinates | 4973335..4973781 (-) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
INN79_RS24500 (4968511) | 4968511..4969407 | + | 897 | WP_001520529.1 | sugar kinase | - |
INN79_RS24505 (4969441) | 4969441..4970244 | + | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
INN79_RS24510 (4970435) | 4970435..4971034 | + | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
INN79_RS24515 (4971028) | 4971028..4971900 | + | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
INN79_RS24520 (4971897) | 4971897..4972334 | + | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
INN79_RS24525 (4972379) | 4972379..4973320 | + | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
INN79_RS24530 (4973335) | 4973335..4973781 | - | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
INN79_RS24535 (4973778) | 4973778..4974089 | - | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
INN79_RS24540 (4974175) | 4974175..4975104 | - | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
INN79_RS24545 (4975322) | 4975322..4975633 | + | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
INN79_RS24550 (4975634) | 4975634..4975924 | + | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
INN79_RS24555 (4975971) | 4975971..4976900 | - | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
INN79_RS24560 (4976897) | 4976897..4977532 | - | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
INN79_RS24565 (4977529) | 4977529..4978431 | - | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T233745 WP_000558166.1 NZ_CP091558:c4974089-4973778 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T233745 NZ_LN649259:2087895-2087987 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT233745 WP_001259011.1 NZ_CP091558:c4973781-4973335 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT233745 NZ_LN649259:c2088141-2087968 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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