Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4973335..4974089 Replicon chromosome
Accession NZ_CP091558
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag INN79_RS24535 Protein ID WP_000558166.1
Coordinates 4973778..4974089 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag INN79_RS24530 Protein ID WP_001259011.1
Coordinates 4973335..4973781 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS24500 (4968511) 4968511..4969407 + 897 WP_001520529.1 sugar kinase -
INN79_RS24505 (4969441) 4969441..4970244 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
INN79_RS24510 (4970435) 4970435..4971034 + 600 WP_000965695.1 glucose-1-phosphatase -
INN79_RS24515 (4971028) 4971028..4971900 + 873 WP_000921427.1 virulence factor BrkB family protein -
INN79_RS24520 (4971897) 4971897..4972334 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
INN79_RS24525 (4972379) 4972379..4973320 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
INN79_RS24530 (4973335) 4973335..4973781 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
INN79_RS24535 (4973778) 4973778..4974089 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
INN79_RS24540 (4974175) 4974175..4975104 - 930 WP_001127703.1 alpha/beta hydrolase -
INN79_RS24545 (4975322) 4975322..4975633 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
INN79_RS24550 (4975634) 4975634..4975924 + 291 WP_000362050.1 DNA-binding transcriptional regulator -
INN79_RS24555 (4975971) 4975971..4976900 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
INN79_RS24560 (4976897) 4976897..4977532 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
INN79_RS24565 (4977529) 4977529..4978431 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T233745 WP_000558166.1 NZ_CP091558:c4974089-4973778 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T233745 NZ_LN649259:2087895-2087987 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT233745 WP_001259011.1 NZ_CP091558:c4973781-4973335 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT233745 NZ_LN649259:c2088141-2087968 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References