Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4712486..4713088 | Replicon | chromosome |
Accession | NZ_CP091556 | ||
Organism | Salmonella enterica strain 632 |
Toxin (Protein)
Gene name | higB | Uniprot ID | C0Q3J8 |
Locus tag | INN80_RS23205 | Protein ID | WP_001159630.1 |
Coordinates | 4712777..4713088 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | INN80_RS23200 | Protein ID | WP_000362050.1 |
Coordinates | 4712486..4712776 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
INN80_RS23185 (4709979) | 4709979..4710881 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
INN80_RS23190 (4710878) | 4710878..4711513 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
INN80_RS23195 (4711510) | 4711510..4712439 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
INN80_RS23200 (4712486) | 4712486..4712776 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | Antitoxin |
INN80_RS23205 (4712777) | 4712777..4713088 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | Toxin |
INN80_RS23210 (4713306) | 4713306..4714235 | + | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
INN80_RS23215 (4714321) | 4714321..4714632 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | - |
INN80_RS23220 (4714629) | 4714629..4715075 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | - |
INN80_RS23225 (4715090) | 4715090..4716031 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
INN80_RS23230 (4716076) | 4716076..4716513 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
INN80_RS23235 (4716510) | 4716510..4717382 | - | 873 | WP_249001048.1 | virulence factor BrkB family protein | - |
INN80_RS23240 (4717376) | 4717376..4717975 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12326.27 Da Isoelectric Point: 9.4460
>T233720 WP_001159630.1 NZ_CP091556:c4713088-4712777 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
Download Length: 312 bp
>T233720 NZ_LN614756:1147503-1147646 [Clostridioides difficile]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTGAAAATCAAGCTTAATAAAAAACAACATTAA
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTGAAAATCAAGCTTAATAAAAAACAACATTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10971.59 Da Isoelectric Point: 10.6525
>AT233720 WP_000362050.1 NZ_CP091556:c4712776-4712486 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
Download Length: 291 bp
>AT233720 NZ_LN614756:c1147718-1147568 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTT
GTTTTTTATTAAGCTTGATTTTCACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTT
GTTTTTTATTAAGCTTGATTTTCACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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