233692

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4379779..4380317 Replicon chromosome
Accession NZ_CP091554
Organism Salmonella enterica strain 751

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag INN81_RS21555 Protein ID WP_001526148.1
Coordinates 4379779..4380054 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag INN81_RS21560 Protein ID WP_000729713.1
Coordinates 4380057..4380317 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN81_RS21550 (4376986) 4376986..4379691 + 2706 WP_000907029.1 HTH-type transcriptional regulator MalT -
INN81_RS21555 (4379779) 4379779..4380054 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
INN81_RS21560 (4380057) 4380057..4380317 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
INN81_RS21565 (4380426) 4380426..4381445 - 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
INN81_RS21570 (4381449) 4381449..4382663 - 1215 WP_001105521.1 RNA-splicing ligase RtcB -
INN81_RS21575 (4383011) 4383011..4384564 - 1554 WP_000013007.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T233692 WP_001526148.1 NZ_CP091554:c4380054-4379779 [Salmonella enterica]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T233692 NZ_LM995446:c1219905-1219798 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT233692 WP_000729713.1 NZ_CP091554:c4380317-4380057 [Salmonella enterica]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT233692 NZ_LM995446:1219952-1220018 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References