23368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2089245..2089747 Replicon chromosome
Accession NC_011742
Organism Escherichia coli S88

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag ECS88_RS11945 Protein ID WP_000767829.1
Coordinates 2089245..2089499 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ECS88_RS11950 Protein ID WP_001259255.1
Coordinates 2089496..2089747 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECS88_RS11920 2084260..2084487 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
ECS88_RS11925 2084501..2085559 - 1059 WP_000492340.1 transport protein YeeE -
ECS88_RS11930 2085738..2087096 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ECS88_RS27360 2087086..2087148 - 63 WP_010723108.1 membrane protein YoeI -
ECS88_RS11935 2087363..2088292 - 930 WP_000803341.1 LysR family transcriptional regulator -
ECS88_RS11940 2088338..2089162 - 825 WP_000754755.1 SDR family oxidoreductase -
ECS88_RS11945 2089245..2089499 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ECS88_RS11950 2089496..2089747 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECS88_RS11955 2090031..2090081 + 51 WP_001364200.1 his operon leader peptide -
ECS88_RS11965 2090227..2091126 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
ECS88_RS11970 2091132..2092436 + 1305 WP_001514311.1 histidinol dehydrogenase -
ECS88_RS11975 2092433..2093503 + 1071 WP_000108976.1 histidinol-phosphate transaminase -
ECS88_RS11980 2093503..2094570 + 1068 WP_000080095.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T23368 WP_000767829.1 NC_011742:c2089499-2089245 [Escherichia coli S88]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T23368 NC_011742:c2089499-2089245 [Escherichia coli S88]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT23368 WP_001259255.1 NC_011742:c2089747-2089496 [Escherichia coli S88]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT23368 NC_011742:c2089747-2089496 [Escherichia coli S88]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References