Detailed information of TA system TA233671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4988382..4988984
• Replicon: chromosome
• Accession: NZ_CP091547
• Organism: Salmonella enterica strain 1559

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L4413_RS24590
• Protein ID: WP_001159630.1
• Coordinates: 4988382..4988693 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L4413_RS24595
• Protein ID: WP_000362050.1
• Coordinates: 4988694..4988984 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4413_RS24555 (4983495)	4983495..4984094	+	600	WP_000965695.1	glucose-1-phosphatase	-
L4413_RS24560 (4984088)	4984088..4984960	+	873	WP_000921427.1	virulence factor BrkB family protein	-
L4413_RS24565 (4984957)	4984957..4985394	+	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
L4413_RS24570 (4985439)	4985439..4986380	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L4413_RS24575 (4986395)	4986395..4986841	-	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
L4413_RS24580 (4986838)	4986838..4987149	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L4413_RS24585 (4987235)	4987235..4988164	-	930	WP_001127703.1	alpha/beta hydrolase	-
L4413_RS24590 (4988382)	4988382..4988693	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L4413_RS24595 (4988694)	4988694..4988984	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L4413_RS24600 (4989031)	4989031..4989960	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L4413_RS24605 (4989957)	4989957..4990592	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L4413_RS24610 (4990589)	4990589..4991491	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233671 WP_001159630.1 NZ_CP091547:4988382-4988693 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233671 NZ_LM993812:c1615593-1615306 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233671 WP_000362050.1 NZ_CP091547:4988694-4988984 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233671 NZ_LM993812:c1615832-1615593 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64