Detailed information of TA system TA233645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4781147..4781749
• Replicon: chromosome
• Accession: NZ_CP091544
• Organism: Salmonella enterica strain 1618

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L4414_RS23450
• Protein ID: WP_001159630.1
• Coordinates: 4781438..4781749 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L4414_RS23445
• Protein ID: WP_000362050.1
• Coordinates: 4781147..4781437 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4414_RS23430 (4778640)	4778640..4779542	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
L4414_RS23435 (4779539)	4779539..4780174	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L4414_RS23440 (4780171)	4780171..4781100	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L4414_RS23445 (4781147)	4781147..4781437	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L4414_RS23450 (4781438)	4781438..4781749	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L4414_RS23455 (4781967)	4781967..4782896	+	930	WP_001127703.1	alpha/beta hydrolase	-
L4414_RS23460 (4782982)	4782982..4783293	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L4414_RS23465 (4783290)	4783290..4783736	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
L4414_RS23470 (4783751)	4783751..4784692	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L4414_RS23475 (4784737)	4784737..4785174	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
L4414_RS23480 (4785171)	4785171..4786043	-	873	WP_000921427.1	virulence factor BrkB family protein	-
L4414_RS23485 (4786037)	4786037..4786636	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233645 WP_001159630.1 NZ_CP091544:c4781749-4781438 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233645 NZ_LC127084:c492426-492223 [Edwardsiella tarda]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233645 WP_000362050.1 NZ_CP091544:c4781437-4781147 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233645 NZ_LC127084:c492815-492447 [Edwardsiella tarda]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGCTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTACCTTACATGTTTAG

Structures

Toxin

• AlphaFold DB: A0A0R9NS64