233637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2528192..2528714 Replicon chromosome
Accession NZ_CP091544
Organism Salmonella enterica strain 1618

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag L4414_RS12485 Protein ID WP_000221343.1
Coordinates 2528430..2528714 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag L4414_RS12480 Protein ID WP_000885424.1
Coordinates 2528192..2528440 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4414_RS12455 (2523408) 2523408..2524874 + 1467 WP_000987828.1 hypothetical protein -
L4414_RS12460 (2525682) 2525682..2526396 + 715 Protein_2446 helix-turn-helix domain-containing protein -
L4414_RS12465 (2526452) 2526452..2527360 - 909 WP_010989018.1 hypothetical protein -
L4414_RS12470 (2527503) 2527503..2527835 - 333 WP_000253154.1 DUF1493 family protein -
L4414_RS12475 (2527825) 2527825..2528040 - 216 WP_000206207.1 hypothetical protein -
L4414_RS12480 (2528192) 2528192..2528440 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L4414_RS12485 (2528430) 2528430..2528714 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L4414_RS12490 (2528885) 2528885..2529274 + 390 WP_000194089.1 RidA family protein -
L4414_RS12495 (2529326) 2529326..2530405 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
L4414_RS12500 (2530598) 2530598..2531086 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
L4414_RS12505 (2531131) 2531131..2532639 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2523411..2535496 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T233637 WP_000221343.1 NZ_CP091544:2528430-2528714 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT233637 WP_000885424.1 NZ_CP091544:2528192-2528440 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References