Detailed information of TA system TA233620

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4815625..4816227
• Replicon: chromosome
• Accession: NZ_CP091542
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5Z53_RS23670
• Protein ID: WP_001159630.1
• Coordinates: 4815916..4816227 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5Z53_RS23665
• Protein ID: WP_000362050.1
• Coordinates: 4815625..4815915 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5Z53_RS23650 (4813118)	4813118..4814020	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
L5Z53_RS23655 (4814017)	4814017..4814652	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5Z53_RS23660 (4814649)	4814649..4815578	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5Z53_RS23665 (4815625)	4815625..4815915	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5Z53_RS23670 (4815916)	4815916..4816227	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5Z53_RS23675 (4816445)	4816445..4817374	+	930	WP_001127703.1	alpha/beta hydrolase	-
L5Z53_RS23680 (4817460)	4817460..4817771	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L5Z53_RS23685 (4817768)	4817768..4818214	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
L5Z53_RS23690 (4818229)	4818229..4819170	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5Z53_RS23695 (4819215)	4819215..4819652	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
L5Z53_RS23700 (4819649)	4819649..4820521	-	873	WP_000921427.1	virulence factor BrkB family protein	-
L5Z53_RS23705 (4820515)	4820515..4821114	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233620 WP_001159630.1 NZ_CP091542:c4816227-4815916 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233620 NZ_HG995459:6046527-6046934 [Pseudomonas sp. PP3]
ATGATCAAATTCATGCTCGATACCAACATCTGCATTTTCACCATAAAGAATAAACCGCAATTTGTAAGAGAAGCCTTCAA
CCGCCATGACGGACAGTTGTGCATCAGTGCTGTGACTCTAATGGAGTTGATCTACGGTGCCGAAAAGTCAGCAGCACCGG
AAAAGAACCTTTCCGTGATCGAAGGCTTCGCGGCGCGCCTTGAAGTTTTGCCCTTCGACAATGAAGCCGCCGCGCATACC
GGGATGATTCGATCCGAGCTGGCGAAGGCTGGAACCCCCATCGGCCCCTACGACCAAATGATTGCCGGGCACGCGCGCTC
ACGCGGGTTCATCGTAGTAACGAATAACCTGCGGGAATTTGAGCGGGTTCCAGGCTTACGTGTAGAAGACTGGGTACACC
CCGGTTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233620 WP_000362050.1 NZ_CP091542:c4815915-4815625 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233620 NZ_HG995459:6046297-6046527 [Pseudomonas sp. PP3]
ATGGAACAGACCACTCTTTTCATGAGCAATCGAAGCCAGGCTGTTCGCCTTCCCAAAGCTGTAGCAATGCCAAGCGACGT
AAAACGGGTCAACGTAGTTGCCATCGGCCGGGCCCGCATCATTACCCCCGCAGACGAAACATGGGATAGCTGGTTCGACG
GGGAAAGCGTATGTCCGGATTTCATGACTGATCGTGACCAACCCACCGATCAGGAGCGTGAGTCGTTTTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64