Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2488244..2488766 Replicon chromosome
Accession NZ_CP091542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag L5Z53_RS12355 Protein ID WP_000221343.1
Coordinates 2488482..2488766 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag L5Z53_RS12350 Protein ID WP_000885424.1
Coordinates 2488244..2488492 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z53_RS12325 (2483460) 2483460..2484926 + 1467 WP_000987828.1 hypothetical protein -
L5Z53_RS12330 (2485734) 2485734..2486448 + 715 Protein_2413 helix-turn-helix domain-containing protein -
L5Z53_RS12335 (2486504) 2486504..2487412 - 909 WP_010989018.1 hypothetical protein -
L5Z53_RS12340 (2487555) 2487555..2487887 - 333 WP_000253154.1 DUF1493 family protein -
L5Z53_RS12345 (2487877) 2487877..2488092 - 216 WP_000206207.1 hypothetical protein -
L5Z53_RS12350 (2488244) 2488244..2488492 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L5Z53_RS12355 (2488482) 2488482..2488766 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L5Z53_RS12360 (2488937) 2488937..2489326 + 390 WP_000194089.1 RidA family protein -
L5Z53_RS12365 (2489378) 2489378..2490457 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
L5Z53_RS12370 (2490650) 2490650..2491138 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
L5Z53_RS12375 (2491183) 2491183..2492691 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2483463..2495548 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T233612 WP_000221343.1 NZ_CP091542:2488482-2488766 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T233612 NZ_HG994851:c4616730-4616557 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT233612 WP_000885424.1 NZ_CP091542:2488244-2488492 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT233612 NZ_HG994851:c4617054-4616758 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References