Detailed information of TA system TA233610

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2119089..2119314
• Replicon: chromosome
• Accession: NZ_CP091542
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: L5Z53_RS10430
• Protein ID: WP_000813254.1
• Coordinates: 2119159..2119314 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2119089..2119147 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5Z53_RS10400	2114527..2115273	+	747	WP_052929112.1	ATP-binding protein	-
L5Z53_RS10405	2115296..2116057	+	762	WP_139707682.1	DUF1627 domain-containing protein	-
L5Z53_RS10410	2116073..2116495	+	423	WP_050306692.1	DUF977 family protein	-
L5Z53_RS10415	2116492..2116692	+	201	WP_042973267.1	hypothetical protein	-
L5Z53_RS10420	2116966..2117544	+	579	WP_001204666.1	sce7726 family protein	-
L5Z53_RS10425	2117504..2118601	-	1098	WP_042973270.1	beta family protein	-
-	2119089..2119147	-	59	-	-	Antitoxin
L5Z53_RS10430	2119159..2119314	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
L5Z53_RS10435	2119590..2119802	+	213	WP_052929182.1	hypothetical protein	-
L5Z53_RS10440	2119874..2120473	+	600	WP_052929183.1	DUF1367 family protein	-
L5Z53_RS10445	2120473..2120763	+	291	WP_001533370.1	DUF1364 domain-containing protein	-
L5Z53_RS10450	2120760..2121302	+	543	WP_000640144.1	DUF1133 family protein	-
L5Z53_RS10455	2121786..2122121	+	336	WP_001533367.1	phage holin, lambda family	-
L5Z53_RS10460	2122125..2122601	+	477	WP_001194114.1	glycoside hydrolase family protein	-
L5Z53_RS10465	2122585..2122977	+	393	WP_042043867.1	DUF2570 domain-containing protein	-
L5Z53_RS10470	2122862..2123140	+	279	WP_173671027.1	hypothetical protein	-
L5Z53_RS10475	2123121..2123306	+	186	WP_000113285.1	hypothetical protein	-
L5Z53_RS10480	2123439..2123987	-	549	WP_000762846.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sopE2	2082820..2164634	81814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T233610 WP_000813254.1 NZ_CP091542:2119159-2119314 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T233610 NZ_HG994851:4308693-4309034 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT233610 NZ_CP091542:c2119147-2119089 [Salmonella enterica subsp. enterica serovar Typhimurium]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin