Detailed information of TA system TA233607

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2106398..2106767
• Replicon: chromosome
• Accession: NZ_CP091542
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A891STD1
• Locus tag: L5Z53_RS10340
• Protein ID: WP_042853000.1
• Coordinates: 2106573..2106767 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2106398..2106574 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5Z53_RS10300 (2101836)	2101836..2102492	-	657	WP_000100258.1	carbon-nitrogen hydrolase family protein	-
L5Z53_RS10305 (2102600)	2102600..2102830	-	231	WP_000856224.1	DNA polymerase III subunit theta	-
L5Z53_RS10310 (2102968)	2102968..2103342	+	375	WP_000168393.1	CopC domain-containing protein YobA	-
L5Z53_RS10315 (2103343)	2103343..2104218	+	876	WP_000979702.1	copper homeostasis membrane protein CopD	-
L5Z53_RS10320 (2104235)	2104235..2104588	+	354	WP_000722368.1	YebY family protein	-
L5Z53_RS10325 (2104962)	2104962..2106038	-	1077	WP_001189085.1	phage integrase Arm DNA-binding domain-containing protein	-
L5Z53_RS10330 (2106004)	2106004..2106285	-	282	WP_023234152.1	excisionase	-
- (2106398)	2106398..2106574	+	177	NuclAT_0	-	Antitoxin
- (2106398)	2106398..2106574	+	177	NuclAT_0	-	Antitoxin
- (2106398)	2106398..2106574	+	177	NuclAT_0	-	Antitoxin
- (2106398)	2106398..2106574	+	177	NuclAT_0	-	Antitoxin
L5Z53_RS10335 (2106392)	2106392..2106580	-	189	WP_052929118.1	DUF1187 family protein	-
L5Z53_RS10340 (2106573)	2106573..2106767	-	195	WP_042853000.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
L5Z53_RS10345 (2106824)	2106824..2107633	-	810	WP_052929117.1	recombination protein RecT	-
L5Z53_RS10350 (2107626)	2107626..2110301	-	2676	WP_052929116.1	exodeoxyribonuclease VIII	-
L5Z53_RS10355 (2110402)	2110402..2110677	-	276	WP_080312066.1	hypothetical protein	-
L5Z53_RS10360 (2110752)	2110752..2110922	-	171	WP_001359121.1	YdaE family protein	-
L5Z53_RS10365 (2110922)	2110922..2111143	-	222	WP_000560226.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sopE2	2082820..2164634	81814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7019.87 Da
• Isoelectric Point: 8.6419

>T233607 WP_042853000.1 NZ_CP091542:c2106767-2106573 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T233607 NZ_HG994851:c3922124-3921726 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 177 bp

>AT233607 NZ_CP091542:2106398-2106574 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGAGA
GCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTTCA
ATAGTGGCAGTTATTTT

Structures

Antitoxin