Detailed information of TA system TA233593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4815753..4816355
• Replicon: chromosome
• Accession: NZ_CP091540
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5Z03_RS23670
• Protein ID: WP_001159630.1
• Coordinates: 4816044..4816355 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5Z03_RS23665
• Protein ID: WP_000362050.1
• Coordinates: 4815753..4816043 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5Z03_RS23650 (4813246)	4813246..4814148	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
L5Z03_RS23655 (4814145)	4814145..4814780	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5Z03_RS23660 (4814777)	4814777..4815706	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5Z03_RS23665 (4815753)	4815753..4816043	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5Z03_RS23670 (4816044)	4816044..4816355	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5Z03_RS23675 (4816573)	4816573..4817502	+	930	WP_001127703.1	alpha/beta hydrolase	-
L5Z03_RS23680 (4817588)	4817588..4817899	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L5Z03_RS23685 (4817896)	4817896..4818342	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
L5Z03_RS23690 (4818357)	4818357..4819298	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5Z03_RS23695 (4819343)	4819343..4819780	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
L5Z03_RS23700 (4819777)	4819777..4820649	-	873	WP_000921427.1	virulence factor BrkB family protein	-
L5Z03_RS23705 (4820643)	4820643..4821242	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T233593 WP_001159630.1 NZ_CP091540:c4816355-4816044 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233593 NZ_HG994851:974424-974831 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233593 WP_000362050.1 NZ_CP091540:c4816043-4815753 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233593 NZ_HG994851:974177-974443 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64