Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2488188..2488710 Replicon chromosome
Accession NZ_CP091540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag L5Z03_RS12345 Protein ID WP_000221343.1
Coordinates 2488426..2488710 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag L5Z03_RS12340 Protein ID WP_000885424.1
Coordinates 2488188..2488436 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z03_RS12315 (2483404) 2483404..2484870 + 1467 WP_000987828.1 hypothetical protein -
L5Z03_RS12320 (2485678) 2485678..2486392 + 715 Protein_2413 helix-turn-helix domain-containing protein -
L5Z03_RS12325 (2486448) 2486448..2487356 - 909 WP_010989018.1 hypothetical protein -
L5Z03_RS12330 (2487499) 2487499..2487831 - 333 WP_000253154.1 DUF1493 family protein -
L5Z03_RS12335 (2487821) 2487821..2488036 - 216 WP_000206207.1 hypothetical protein -
L5Z03_RS12340 (2488188) 2488188..2488436 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L5Z03_RS12345 (2488426) 2488426..2488710 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L5Z03_RS12350 (2488881) 2488881..2489270 + 390 WP_000194089.1 RidA family protein -
L5Z03_RS12355 (2489322) 2489322..2490401 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
L5Z03_RS12360 (2490594) 2490594..2491082 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
L5Z03_RS12365 (2491127) 2491127..2492635 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2483407..2495492 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T233585 WP_000221343.1 NZ_CP091540:2488426-2488710 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T233585 NZ_HG994850:4236357-4236509 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT233585 WP_000885424.1 NZ_CP091540:2488188-2488436 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT233585 NZ_HG994850:c4236308-4236251 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References