Detailed information of TA system TA233580

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2106342..2106711
• Replicon: chromosome
• Accession: NZ_CP091540
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A891STD1
• Locus tag: L5Z03_RS10330
• Protein ID: WP_042853000.1
• Coordinates: 2106517..2106711 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2106342..2106518 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5Z03_RS10290 (2101780)	2101780..2102436	-	657	WP_000100258.1	carbon-nitrogen hydrolase family protein	-
L5Z03_RS10295 (2102544)	2102544..2102774	-	231	WP_000856224.1	DNA polymerase III subunit theta	-
L5Z03_RS10300 (2102912)	2102912..2103286	+	375	WP_000168393.1	CopC domain-containing protein YobA	-
L5Z03_RS10305 (2103287)	2103287..2104162	+	876	WP_000979702.1	copper homeostasis membrane protein CopD	-
L5Z03_RS10310 (2104179)	2104179..2104532	+	354	WP_000722368.1	YebY family protein	-
L5Z03_RS10315 (2104906)	2104906..2105982	-	1077	WP_001189085.1	phage integrase Arm DNA-binding domain-containing protein	-
L5Z03_RS10320 (2105948)	2105948..2106229	-	282	WP_023234152.1	excisionase	-
- (2106342)	2106342..2106518	+	177	NuclAT_0	-	Antitoxin
- (2106342)	2106342..2106518	+	177	NuclAT_0	-	Antitoxin
- (2106342)	2106342..2106518	+	177	NuclAT_0	-	Antitoxin
- (2106342)	2106342..2106518	+	177	NuclAT_0	-	Antitoxin
L5Z03_RS10325 (2106336)	2106336..2106524	-	189	WP_052929118.1	DUF1187 family protein	-
L5Z03_RS10330 (2106517)	2106517..2106711	-	195	WP_042853000.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
L5Z03_RS10335 (2106768)	2106768..2107577	-	810	WP_052929117.1	recombination protein RecT	-
L5Z03_RS10340 (2107570)	2107570..2110245	-	2676	WP_052929116.1	exodeoxyribonuclease VIII	-
L5Z03_RS10345 (2110346)	2110346..2110621	-	276	WP_080312066.1	hypothetical protein	-
L5Z03_RS10350 (2110696)	2110696..2110866	-	171	WP_001359121.1	YdaE family protein	-
L5Z03_RS10355 (2110866)	2110866..2111087	-	222	WP_000560226.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sopE2	2082764..2165138	82374

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7019.87 Da
• Isoelectric Point: 8.6419

>T233580 WP_042853000.1 NZ_CP091540:c2106711-2106517 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T233580 NZ_CP091540:c2106711-2106517 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCTGTTACGGTGAAAGCAATTTCAGGATATTACAG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CTACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 177 bp

>AT233580 NZ_CP091540:2106342-2106518 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGAGA
GCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTTCA
ATAGTGGCAGTTATTTT

Structures

Antitoxin