Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1937221..1937723 Replicon chromosome
Accession NZ_CP091534
Organism Escherichia coli strain 537-20

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag L6D13_RS09225 Protein ID WP_000767829.1
Coordinates 1937469..1937723 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag L6D13_RS09220 Protein ID WP_001259255.1
Coordinates 1937221..1937472 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D13_RS09195 (1932399) 1932399..1933466 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
L6D13_RS09200 (1933466) 1933466..1934536 - 1071 WP_001362957.1 histidinol-phosphate transaminase -
L6D13_RS09205 (1934533) 1934533..1935837 - 1305 WP_001774536.1 histidinol dehydrogenase -
L6D13_RS09210 (1935843) 1935843..1936742 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
L6D13_RS09215 (1936888) 1936888..1936938 - 51 WP_001364200.1 his operon leader peptide -
L6D13_RS09220 (1937221) 1937221..1937472 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
L6D13_RS09225 (1937469) 1937469..1937723 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
L6D13_RS09230 (1937806) 1937806..1938630 + 825 WP_000754758.1 SDR family oxidoreductase -
L6D13_RS09235 (1938676) 1938676..1939605 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
L6D13_RS09240 (1939820) 1939820..1939882 + 63 WP_010723108.1 membrane protein YoeI -
L6D13_RS09245 (1939872) 1939872..1941230 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
L6D13_RS09250 (1941409) 1941409..1942467 + 1059 WP_000492315.1 thiosulfate utilization transporter TsuA/YeeE -
L6D13_RS09255 (1942481) 1942481..1942708 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-84)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T233546 WP_000767829.1 NZ_CP091534:1937469-1937723 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T233546 NZ_HG992341:c5015569-5015288 [Xanthomonas arboricola pv. corylina]
ATGATCAGGAGCTTTGTCGACAAGGAAGCCGAAAAGATCTGGATGGGTGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GTCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGCATTCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCGAGCGGCGCGGGCAGTACAGCATCCGGATCAACGACCAGTGGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGAAATTGTTGATTACCACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT233546 WP_001259255.1 NZ_CP091534:1937221-1937472 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT233546 NZ_HG992341:c5015270-5014980 [Xanthomonas arboricola pv. corylina]
ATGACAGTCCTACCCAACATCCACCCTGGCGAAATCCTGCGCGAAGAGTTCCTCGAGCCGATGGGCATCAGCCAGAACGC
GCTGGCGCGGGCCACCGGCGTACCGCCGCGTCGCATCAACGAGATCGTCCTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCCTGGCTGCAGCGCTGGGCACGACCGAGCGCTTCTGGCTGAGCCTGCAAGCCGATTACGAGCTGGAACAGGCA
CACCGCGCGCTGGGCGATCTGCCGTCGCGGATCAAGCGGCTGGCGGCTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q


Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References