Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 791002..791695 Replicon chromosome
Accession NZ_CP091534
Organism Escherichia coli strain 537-20

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L6D13_RS03850 Protein ID WP_000415584.1
Coordinates 791002..791298 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L6D13_RS03855 Protein ID WP_000650107.1
Coordinates 791300..791695 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D13_RS03820 (786677) 786677..786991 - 315 WP_000958598.1 putative quinol monooxygenase -
L6D13_RS03825 (787022) 787022..787603 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L6D13_RS03830 (787713) 787713..789062 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
L6D13_RS03835 (789059) 789059..789718 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
L6D13_RS03840 (789870) 789870..790262 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L6D13_RS03845 (790315) 790315..790797 + 483 WP_000183494.1 GyrI-like domain-containing protein -
L6D13_RS03850 (791002) 791002..791298 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L6D13_RS03855 (791300) 791300..791695 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L6D13_RS03860 (791828) 791828..793435 + 1608 WP_001324265.1 ABC transporter substrate-binding protein -
L6D13_RS03865 (793573) 793573..795831 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 779274..791695 12421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T233539 WP_000415584.1 NZ_CP091534:791002-791298 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T233539 NZ_HG992338:74291-74560 [Xanthomonas arboricola pv. corylina]
GTGGCCGACCTGGACGCGATTGCCGACTACATTGCGCTTGAGGACGCTGCCGCCGCAGCGGCACTGGTGAGACGGGTGTT
TGCGCATGTCGAGCAATTGGCCGAACACCCGGAGAGTGGAAGCCGGCCGCAGGAGCTCAAGCGCTCCCGCTACCGTCAAA
TCGTCGAGCCACCTTGCCGCGTGTTCTACCGTGTGGACGGGCAACGCGTTGTCGTGGTTCACGTGATGCGCTCGGAGCGG
TTACTTCGGAAGAATCGTCTTTCGCGCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT233539 WP_000650107.1 NZ_CP091534:791300-791695 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT233539 NZ_HG992338:74016-74273 [Xanthomonas arboricola pv. corylina]
ATGCGCACAGAACTTGTCACCACGCTCAAGCGGCAGGCCACCGAGCTCCTCGCAGATGTCGAGCGCGACAAGGAGCCGAT
CCTGATCACCCAGCATGGCCTGCCCAGCGCATACCTGGTGGACGTCGCCAGCTATGAACGCATGCAACAGCGCATGGCGA
TCCTCGAAGGAATTGCCCGTGGTGAAATGGCGGTAGCCGAAGGCCGCAGCCTGAGCCACGAGCAAGCCAAACAACGCCTG
GCGCGATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References