Detailed information of TA system TA233512

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2417375..2417559
• Replicon: chromosome
• Accession: NZ_CP091525
• Organism: Staphylococcus aureus strain N09CSA16

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: L4X60_RS11845
• Protein ID: WP_000482652.1
• Coordinates: 2417375..2417482 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2417499..2417559 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4X60_RS11820	2412737..2413210	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
L4X60_RS11825	2413333..2414544	-	1212	WP_001192073.1	multidrug effflux MFS transporter	-
L4X60_RS11830	2414726..2415385	-	660	WP_000831298.1	membrane protein	-
L4X60_RS11835	2415445..2416587	-	1143	WP_001176863.1	glycerate kinase	-
L4X60_RS11840	2416855..2417241	+	387	WP_000779360.1	flippase GtxA	-
L4X60_RS11845	2417375..2417482	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2417499..2417559	-	61	-	-	Antitoxin
L4X60_RS11850	2418185..2419948	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
L4X60_RS11855	2419973..2421706	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
L4X60_RS11860	2421973..2422104	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T233512 WP_000482652.1 NZ_CP091525:2417375-2417482 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T233512 NZ_HG969191:894320-894652 [Bartonella henselae]
ATGAAGCGGGGCGAAATTTGGCTTGTATCTCTTGACCCAACTTCAGGCTATGAACAAAAAGGAACGCGTCCTGTATTGAT
TGTATCACCAGAGGCGTTTAATCGTGTCACGAAAACACCCATTGTCTTACCCATTACAAGTGGAGGAAATTTTTCTCGAA
CCGCAGGTTTCGCTGTCTCATTGGTAGGAACAGGATTGCATACAACAGGTGTGATACGTTGTGACCAGCCACGTGCTCTG
GATATAGCAGCGCGTCAGGGTAAGAAAATGGAAACAGTTCCCCCCATAATTATGAACGAAGTTCTTGCTAAGCTATCAAC
ATTTCTCACATAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT233512 NZ_CP091525:c2417559-2417499 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin