Detailed information of TA system TA233507

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 507282..507861
• Replicon: chromosome
• Accession: NZ_CP091525
• Organism: Staphylococcus aureus strain N09CSA16

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: L4X60_RS02725
• Protein ID: WP_001025401.1
• Coordinates: 507282..507527 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	507496..507861 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4X60_RS02685 (502367)	502367..503572	-	1206	WP_000264751.1	site-specific integrase	-
L4X60_RS02690 (503698)	503698..504312	+	615	WP_000191470.1	hypothetical protein	-
L4X60_RS02695 (504309)	504309..504455	-	147	WP_001795334.1	hypothetical protein	-
L4X60_RS02700 (504685)	504685..505269	-	585	WP_000825949.1	hypothetical protein	-
L4X60_RS02705 (505287)	505287..505748	-	462	WP_000525004.1	hypothetical protein	-
L4X60_RS02710 (505761)	505761..506075	-	315	WP_000333631.1	helix-turn-helix transcriptional regulator	-
L4X60_RS02715 (506227)	506227..506463	+	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
L4X60_RS02720 (506477)	506477..507253	+	777	WP_153906478.1	Rha family transcriptional regulator	-
L4X60_RS02725 (507282)	507282..507527	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
L4X60_RS02730 (507496)	507496..507861	-	366	WP_001128433.1	hypothetical protein	Antitoxin
L4X60_RS02735 (507916)	507916..508131	+	216	WP_001097552.1	hypothetical protein	-
L4X60_RS02740 (508158)	508158..508421	+	264	WP_001124194.1	helix-turn-helix domain-containing protein	-
L4X60_RS02745 (508434)	508434..508595	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
L4X60_RS02750 (508674)	508674..508997	+	324	WP_000174999.1	hypothetical protein	-
L4X60_RS02755 (509012)	509012..509374	+	363	WP_000985972.1	hypothetical protein	-
L4X60_RS02760 (509371)	509371..510537	+	1167	WP_000762552.1	DUF2800 domain-containing protein	-
L4X60_RS02765 (510563)	510563..511120	+	558	WP_000645048.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T233507 WP_001025401.1 NZ_CP091525:507282-507527 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T233507 NZ_HG969191:c786838-786566 [Bartonella henselae]
ATGAAGCTCGTTTGGACACGGATAGCGCATTACGATCGTCAAAAGATACGGGAATATATCGCGCAAGAAAATCCTTCTGC
TGCATTAGTATTCGACAAGCTTTTATCTAAAAAAGTAGAAAGACTCATTAGCTTTCCTAATCTTGGTCGTGTTGGCCGAA
TTAGGAATACGCGCGAGCTTATTGTGCGTAAGAATTATATTATGATTTATGATGTTTCTAATGGCACTATACGGGTTTTG
CGCATACTTCACGCAAAACAAAAGTGGCCATAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT233507 NZ_CP091525:c507861-507496 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin