Detailed information of TA system TA233495

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2678999..2679277
• Replicon: chromosome
• Accession: NZ_CP091523
• Organism: Staphylococcus aureus strain N12HSA28

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: L5471_RS13140
• Protein ID: WP_001802298.1
• Coordinates: 2678999..2679103 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2679099..2679277 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5471_RS13125	2675795..2676577	+	783	WP_000908178.1	ABC transporter ATP-binding protein	-
L5471_RS13130	2676645..2677502	+	858	WP_000370917.1	HAD family hydrolase	-
L5471_RS13135	2678161..2678319	-	159	WP_001792784.1	hypothetical protein	-
L5471_RS13140	2678999..2679103	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2679099..2679277	-	179	-	-	Antitoxin
L5471_RS13150	2679536..2680627	-	1092	WP_000495683.1	hypothetical protein	-
L5471_RS13155	2680893..2681873	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
L5471_RS13160	2681875..2682195	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
L5471_RS13165	2682347..2683012	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T233495 WP_001802298.1 NZ_CP091523:2678999-2679103 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T233495 NZ_HG965802:406071-406385 [Bartonella henselae]
ATGATACATAAAAGAACGAATGAAGGTGACTTGGTAATTGAATCTTTTGCGGATAAGCGGTGTAAAGATCTTTTAGAAGG
CAATCCACCTAAAGGTTTTCCCACAACTCTCGTGCGTATAGTCCAACGAAAATTATTTATGCTGGATAAAGCAGTTGATC
TCAAAGATTTACGCAGTCCTCCGGGTAATCGTTTAGAGGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATT
AATGACCAGTTTCGCATTTGTTTTGAGTGGCGTTCTAATGGTGCCTATGAAGTTGAAATCGTCGATTATCATTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT233495 NZ_CP091523:c2679277-2679099 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin