Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2400503..2400687 Replicon chromosome
Accession NZ_CP091523
Organism Staphylococcus aureus strain N12HSA28

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag L5471_RS11690 Protein ID WP_000482647.1
Coordinates 2400503..2400610 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2400627..2400687 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5471_RS11665 2395875..2396348 + 474 WP_000456497.1 GyrI-like domain-containing protein -
L5471_RS11670 2396471..2397682 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
L5471_RS11675 2397864..2398523 - 660 WP_000831301.1 membrane protein -
L5471_RS11680 2398583..2399725 - 1143 WP_001176871.1 glycerate kinase -
L5471_RS11685 2399983..2400369 + 387 WP_000779360.1 flippase GtxA -
L5471_RS11690 2400503..2400610 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2400627..2400687 - 61 - - Antitoxin
L5471_RS11695 2401294..2403057 + 1764 WP_001064816.1 ABC transporter ATP-binding protein -
L5471_RS11700 2403082..2404815 + 1734 WP_000486494.1 ABC transporter ATP-binding protein -
L5471_RS11705 2405046..2405213 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T233491 WP_000482647.1 NZ_CP091523:2400503-2400610 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T233491 NZ_HG941719:22958-23116 [Escherichia coli O25b:H4-ST131]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 61 bp

>AT233491 NZ_CP091523:c2400687-2400627 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References