233490

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2368974..2369497 Replicon chromosome
Accession NZ_CP091523
Organism Staphylococcus aureus strain N12HSA28

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag L5471_RS11550 Protein ID WP_000074048.1
Coordinates 2369231..2369497 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag L5471_RS11545 Protein ID WP_000587616.1
Coordinates 2368974..2369231 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5471_RS11530 (2365470) 2365470..2366219 - 750 WP_000072445.1 CPBP family lipoprotein N-acylation protein LnsB -
L5471_RS11535 (2366415) 2366415..2367992 + 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
L5471_RS11540 (2368160) 2368160..2368615 - 456 WP_000732082.1 DUF1307 domain-containing protein -
L5471_RS11545 (2368974) 2368974..2369231 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L5471_RS11550 (2369231) 2369231..2369497 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
L5471_RS11555 (2369853) 2369853..2370929 + 1077 WP_001076671.1 M42 family metallopeptidase -
L5471_RS11560 (2371177) 2371177..2371839 + 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
L5471_RS11565 (2371832) 2371832..2372608 + 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
L5471_RS11570 (2373004) 2373004..2374191 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T233490 WP_000074048.1 NZ_CP091523:2369231-2369497 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T233490 NZ_HG941719:628-933 [Escherichia coli O25b:H4-ST131]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT233490 WP_000587616.1 NZ_CP091523:2368974-2369231 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT233490 NZ_HG941719:408-626 [Escherichia coli O25b:H4-ST131]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References