Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15454..15712 Replicon chromosome
Accession NC_011742
Organism Escherichia coli S88

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag ECS88_RS00915 Protein ID WP_000809168.1
Coordinates 15454..15606 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15655..15712 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECS88_RS00895 10699..11412 - 714 WP_001102393.1 acidic protein MsyB -
ECS88_RS00900 11438..11842 - 405 WP_000843687.1 DUF2541 family protein -
ECS88_RS00905 12214..14130 + 1917 WP_000516135.1 molecular chaperone DnaK -
ECS88_RS00910 14219..15349 + 1131 WP_001118464.1 molecular chaperone DnaJ -
ECS88_RS00915 15454..15606 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15655..15712 + 58 - - Antitoxin
ECS88_RS00920 16218..16979 + 762 WP_001274823.1 hypothetical protein -
ECS88_RS00925 16999..18492 + 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
ECS88_RS00930 18621..19880 + 1260 WP_000494924.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T23348 WP_000809168.1 NC_011742:c15606-15454 [Escherichia coli S88]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T23348 NC_011742:c15606-15454 [Escherichia coli S88]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT23348 NC_011742:15655-15712 [Escherichia coli S88]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References