Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2202452..2203033 | Replicon | chromosome |
| Accession | NZ_CP091522 | ||
| Organism | Neisseria sp. Dent CA1/247 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LVJ85_RS10850 | Protein ID | WP_244739824.1 |
| Coordinates | 2202755..2203033 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LVJ85_RS10845 | Protein ID | WP_107689158.1 |
| Coordinates | 2202452..2202745 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ85_RS10820 (LVJ85_10820) | 2197707..2198432 | - | 726 | WP_244738480.1 | IS21-like element helper ATPase IstB | - |
| LVJ85_RS10825 (LVJ85_10825) | 2198422..2199954 | - | 1533 | WP_182073206.1 | IS21 family transposase | - |
| LVJ85_RS10830 (LVJ85_10830) | 2200146..2200580 | - | 435 | WP_244739821.1 | DUF29 domain-containing protein | - |
| LVJ85_RS10835 (LVJ85_10835) | 2201374..2201970 | - | 597 | WP_244739822.1 | LexA family transcriptional regulator | - |
| LVJ85_RS10840 (LVJ85_10840) | 2202102..2202302 | + | 201 | WP_244739823.1 | Cro/CI family transcriptional regulator | - |
| LVJ85_RS10845 (LVJ85_10845) | 2202452..2202745 | - | 294 | WP_107689158.1 | HigA family addiction module antitoxin | Antitoxin |
| LVJ85_RS10850 (LVJ85_10850) | 2202755..2203033 | - | 279 | WP_244739824.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LVJ85_RS10855 (LVJ85_10855) | 2203076..2203888 | + | 813 | WP_244739825.1 | hypothetical protein | - |
| LVJ85_RS10860 (LVJ85_10860) | 2204391..2204639 | + | 249 | WP_009116123.1 | MazE family transcriptional regulator | - |
| LVJ85_RS10865 (LVJ85_10865) | 2204633..2204953 | + | 321 | WP_040667449.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| LVJ85_RS10870 (LVJ85_10870) | 2205137..2205418 | + | 282 | WP_244739826.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| LVJ85_RS10875 (LVJ85_10875) | 2205415..2205819 | + | 405 | WP_244739827.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ85_RS10880 (LVJ85_10880) | 2205937..2206185 | + | 249 | WP_085360212.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| LVJ85_RS10885 (LVJ85_10885) | 2206182..2206442 | + | 261 | WP_085360210.1 | Txe/YoeB family addiction module toxin | - |
| LVJ85_RS10890 (LVJ85_10890) | 2206492..2206962 | - | 471 | WP_244739828.1 | hypothetical protein | - |
| LVJ85_RS10895 (LVJ85_10895) | 2207585..2207875 | + | 291 | WP_244739829.1 | phosphoglycerate kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2195870..2235064 | 39194 | |
| - | flank | IS/Tn | - | - | 2197707..2198432 | 725 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10774.34 Da Isoelectric Point: 9.2990
>T233476 WP_244739824.1 NZ_CP091522:c2203033-2202755 [Neisseria sp. Dent CA1/247]
MIQTFNCKHTEQLFQGRCPLKFRAIQKAAERKLQMLDSAVTVDFLRSPPGNRLEALKGSRTGQFSIRINDQWRVCFRFEN
GHAYDVEIVDYH
MIQTFNCKHTEQLFQGRCPLKFRAIQKAAERKLQMLDSAVTVDFLRSPPGNRLEALKGSRTGQFSIRINDQWRVCFRFEN
GHAYDVEIVDYH
Download Length: 279 bp
>T233476 NZ_HG941718:3356274-3356651 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10944.61 Da Isoelectric Point: 6.7234
>AT233476 WP_107689158.1 NZ_CP091522:c2202745-2202452 [Neisseria sp. Dent CA1/247]
MNNQMRPIHPGEILREEYLIPLGMTANALSVALHVPAPRINDIVREKRGISPDTALRLARYFGGDAQSWLNLQNAYDLKV
AEQSLKQEIDHIIPMQA
MNNQMRPIHPGEILREEYLIPLGMTANALSVALHVPAPRINDIVREKRGISPDTALRLARYFGGDAQSWLNLQNAYDLKV
AEQSLKQEIDHIIPMQA
Download Length: 294 bp
>AT233476 NZ_HG941718:3355817-3356197 [Escherichia coli O25b:H4-ST131]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACTCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACTCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|