Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1782791..1783306 Replicon chromosome
Accession NZ_CP091507
Organism Uruburuella suis strain 1258/02

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LVJ78_RS08100 Protein ID WP_243650332.1
Coordinates 1783115..1783306 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LVJ78_RS08095 Protein ID WP_243650331.1
Coordinates 1782791..1783093 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ78_RS08070 (LVJ78_08070) 1777820..1778572 - 753 WP_132953269.1 amino acid ABC transporter ATP-binding protein -
LVJ78_RS08075 (LVJ78_08075) 1778585..1779301 - 717 WP_132953337.1 amino acid ABC transporter permease -
LVJ78_RS08080 (LVJ78_08080) 1779291..1780121 - 831 WP_132953267.1 amino acid ABC transporter substrate-binding protein -
LVJ78_RS08085 (LVJ78_08085) 1780285..1782141 - 1857 WP_132953265.1 M48 family metalloprotease -
LVJ78_RS08090 (LVJ78_08090) 1782159..1782746 - 588 WP_132953263.1 LemA family protein -
LVJ78_RS08095 (LVJ78_08095) 1782791..1783093 - 303 WP_243650331.1 HigA family addiction module antitoxin Antitoxin
LVJ78_RS08100 (LVJ78_08100) 1783115..1783306 - 192 WP_243650332.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ78_RS08105 (LVJ78_08105) 1783521..1785458 + 1938 WP_132953261.1 DNA mismatch repair endonuclease MutL -
LVJ78_RS08110 (LVJ78_08110) 1785461..1785670 - 210 WP_132953259.1 hypothetical protein -
LVJ78_RS08115 (LVJ78_08115) 1785779..1787518 - 1740 WP_132953257.1 bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase -
LVJ78_RS08120 (LVJ78_08120) 1787511..1788227 - 717 WP_132953255.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-63)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-67)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7317.42 Da        Isoelectric Point: 8.2990

>T233451 WP_243650332.1 NZ_CP091507:c1783306-1783115 [Uruburuella suis]
MRKLQQLNAAADLSFLKIPPGNRLEALKDNRQGQHSIRINDQWRICFIWANGHACCVEIVDYH

Download         Length: 192 bp

>T233451 NZ_HG938356:c165297-164926 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGATCCGCAGCAACGTGCCGAGGCGCGGCGATGTCTACTGGATCGACCCAAACCCCGTCGCCGGCCGGGAAATGAAGAA
CCGGCATCGTTTCGTTGTCATCACACCGATCGAGATCAGCAGGCTGGGCGTCAGCATGACGGTGCCCATCACCACCGGTG
GGGCTTTTATCCGCGATGTCGGTCTTGCGGTGGCGATTTCCGGGCACGACACGACCGGCGTCGCCGTTTGCAACCAGGTC
CGCAGCTTCGACATTCCCGCCCGCATCCAGCAGAAAACCGCGCAATATATCGAGACGCTGGACGAGGCGACGATGAATGA
AATCGTCTCGCGCGTGGTCAGCGCCATCGACCCGGCACCTGAACCCGCCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11446.26 Da        Isoelectric Point: 7.4674

>AT233451 WP_243650331.1 NZ_CP091507:c1783093-1782791 [Uruburuella suis]
MMNMREIPLAHPGEILLEDWLKPMNISQYALAKAIDVPPRRINEIVKGKRAITADTALRLAAFFNTDAQSWLNLQSHYDA
ENTRVAIAEQLKHIHPYHMA

Download         Length: 303 bp

>AT233451 NZ_HG938356:c165560-165297 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGCCGGTCACCACCAAAATCAGACGCCAAGGCGGTGCCGCGGTGATTACCATCCCCCCGGCCCTGTTGAAGCTGATGCA
TACCGAAGTCGGCGATCAGCTGACGCTCGACGTCGCCAACGGTGAATTGATCGCCCGTCCCGTCGAGAACGGCCGCAAGC
GCTACACCCTTAGCGAATTGCTGAAGGGAAGCGATGCTATGGCGATGCTGAATGCCGCTGTCGCCGATGCGCAGGAAGGC
GATCCGATAGGACACGAGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References